Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery

Li, Junjie; Zhao, Rui; Miao, Peiran; Xu, Fengfeng; Chen, Jiahao; Jiang, Xiaoying; Hui, Zi; Wang, Liwei; Bai, Renren

doi:10.1016/j.ejmech.2023.115791

Cited by 17 publications

(2 citation statements)

References 163 publications

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“…The antifungal activity of NDGA is also attributed to its ability to inhibit microbial growth and cell function. Li et al (2023) suggested that NDGA may inhibit the synthesis of pro-in ammatory molecules such as Tumor Necrosis Factor-alpha (TNF-α), which may contribute to its antifungal action.…”

Section: Antifungal Activitiesmentioning

confidence: 99%

Polyphenolic Bioactive Compounds from Larrea tridentata (DC.) Coville: Extraction, Characterization, Antioxidant, and Antifungal Activities

Bamidele,

Pérez,

Sandoval-Cortes

et al. 2024

Preprint

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The significance of medicinal plants in inhibiting microbial growth in food and agricultural production as well as their economic viability cannot be overstated. These plants contain secondary metabolites, which are abundant in antimicrobial compounds, such as flavonoids, tannins, saponins, and alkaloids, and their extracts have demonstrated antimicrobial properties against a variety of plant pathogens. The primary objective of this study was to explore the possibility of using bioactive compounds in plant defenses and their biological applications. To achieve this, antifungal polyphenolic bioactive compounds were extracted from the stems and leaves of L. tridentata using conventional methods. The total polyphenol and antioxidant potential of the extracts were assessed and characterized using high-performance liquid chromatography (HPLC). This study compared the polyphenolic constituents of extracts from emerging maceration and Soxhlet extraction techniques in the leaves and stems of Larrea tridentata. The extracts were evaluated for total polyphenolic content (hydrolyzable (HT) and condensed tannins (CT)) and antioxidant activity (ABTS, FRAP, and DPPH). Reverse-Phase High-Performance Liquid Chromatography Electrospray Ionization coupled with mass spectrometry (RP-HPLC-ESI-MS) was used for qualitative identification of antimicrobial phytochemicals. Furthermore, the extracts were analyzed in vitro for antifungal activity against Fusarium oxysporum and Alternaria alternata. The results revealed that 60:40 ethanol:water macerated leaf extract gave the highest hydrolysable tannins (6.41 ± 0.08 mg GAE/g), while its equivalent showed the highest condensed tannins (2.81 mg CE/g). Soxhlet ethyl acetate leaf (SOX ELL) extract showed 1.14 times more condensed tannin content than that of the stems. The antioxidant potential of the extract increased with increasing polarity of the extraction solvent. SOX ELL had higher antifungal effects against F. oxysporum and A. alternata, whereas the 60:40 ethanol: water ratio resulted in 52% inhibition against A. alternata and 43% inhibition against F. oxysporum. Polyphenols with antifungal properties were found in the extracts, including caffeic acid 4-O-glucoside, rhamnetin, protocatechuic acid 4-O-glucoside, kaempferol, (+)-gallocatechin, luteolin, guteolin 7-O-(2-apiosyl-glucoside), gallic acid 4-O-glucoside, cumaric acid 4-O-glucoside, quercetin, NDGA, piceatannol 3-O-glucoside, pterostilbene, tetramethylscutellarein, and cirsimaritin. L. tridentata leaf extracts exhibit potential effectiveness in the development of biological control agents, which can not only enhance crop protection, but also contribute to overall agricultural sustainability.

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Section: Antifungal Activitiesmentioning

confidence: 99%

Polyphenolic Bioactive Compounds from Larrea tridentata (DC.) Coville: Extraction, Characterization, Antioxidant, and Antifungal Activities

Bamidele,

Pérez,

Sandoval-Cortes

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The first group includes primary metabolites involved in plant growth, development, reproduction, and metabolism, while the second one consists of secondary metabolites, which are able to protect plants from injury and diseases [33]. Among the latter, flavonoids are largely studied for their capability to protect and mitigate several diseases, exerting many different biological effects such as cardio-protective [34], anti-cancer [35,36], neuroprotective [37], antioxidant [38], and anti-obesity effects, as well as their role in the management of insulin resistance [39,40]. Interestingly, several scientific reports highlighted the beneficial effects of flavonoids contained in both Citrus fruits and their juices that, together with their byproducts [41], represent a real treasure for human health [42,43], for their capability to target multiple molecular targets [44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Lombardo,

Russo,

Maugeri

et al. 2024

IJMS

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Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer. Nowadays, it is well-known that Citrus fruits, typical of the Mediterranean diet, are an important source of bioactive compounds, such as polyphenols. Among these, flavonoids are recognized as potential agents endowed with a wide range of beneficial properties, including antioxidant, anti-inflammatory, hypolipidemic, and antitumoral ones. On these bases, we offer a comprehensive overview on biological effects exerted by Citrus flavonoids via targeting SIRTs, which acted as modulator of several signaling pathways. According to the reported studies, Citrus flavonoids appear to be promising SIRT modulators in many different pathologies, a role which might be potentially evaluated in future therapies, along with encouraging the study of those SIRT members which still lack proper evidence on their support.

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Iron(III) Triflate‐Assisted Skeletal Rearrangement of Warfarin Framework: A Direct Synthetic Route to a Diverse Series of Biorelevant Flavone‐Coumarin Molecular Hybrids

Bhowmick,

Brahmachari

2024

Asian J Org Chem

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We herein disclose a new synthetic strategy for a diverse series of biologically interesting flavone‐coumarin molecular hybrids based on iron(III) triflate‐assisted direct and straightforward skeletal rearrangement of warfarin framework upon heating warfarin analogs in N, N‐dimethylformamide (DMF). Good yields, reasonable reaction time, broad substrate scope and tolerance of various functional groups, scalability, and operational simplicity are the key features of this newly developed method.

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Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery

Cited by 17 publications

References 163 publications

Polyphenolic Bioactive Compounds from Larrea tridentata (DC.) Coville: Extraction, Characterization, Antioxidant, and Antifungal Activities

Polyphenolic Bioactive Compounds from Larrea tridentata (DC.) Coville: Extraction, Characterization, Antioxidant, and Antifungal Activities

Sirtuins as Players in the Signal Transduction of Citrus Flavonoids

Iron(III) Triflate‐Assisted Skeletal Rearrangement of Warfarin Framework: A Direct Synthetic Route to a Diverse Series of Biorelevant Flavone‐Coumarin Molecular Hybrids

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