Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability

Zhao, Shujie; Wang, Ya; Zhang, Xujie; Qiao, Lijun; Wang, Shuo; Jin, Yu; Wu, Shuo; Li, Yuhuan; Zhan, Peng; Liu, Xinyong

doi:10.1039/d3md00461a

RSC Med. Chem.

2023

DOI: 10.1039/d3md00461a

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Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability

Shujie Zhao,

Ya Wang,

Xujie Zhang

et al.

Abstract: Novel HBV capsid assembly modulators, 6a-25 and 6b-9, showed significantly improved metabolic stability compared to the lead compound GLS4.

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2024

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Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability

Abstract: Novel HBV capsid assembly modulators, 6a-25 and 6b-9, showed significantly improved metabolic stability compared to the lead compound GLS4.

Cited by 2 publications

References 47 publications

Novel mechanistic insights – A brand new Era for anti-HBV drugs

Novel mechanistic insights – A brand new Era for anti-HBV drugs

Discovery of selective LATS inhibitors via scaffold hopping: enhancing drug-likeness and kinase selectivity for potential applications in regenerative medicine

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