Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis

Aboushaala, Khaled; Chee, Ana V.; Toro, Sheila J.; Vucicevic, Rajko; Yuh, Catherine; Dourdourekas, Jake; Patel, Ishani K.; Espinoza-Orias, Alejandro; Oh, Chundo; Al-Harthi, Lena; Karppinen, Jaro; Goldberg, Edward J.; Phillips, Frank M.; Colman, Matthew; Williams, Frances M. K.; Borgia, Jeffrey A.; Green, Stefan; Forsyth, Christopher; An, Howard S.; Samartzis, Dino

doi:10.1007/s00586-024-08192-y

Cited by 2 publications

(3 citation statements)

References 45 publications

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“…Some of the cytokines and chemokines we measured with the V‐Plex were measured in earlier studies 5 , 6 , 7 , 8 , 10 but the previous positive findings could not be reproduced in our larger dataset and also not in the other studies mentioned. This can have technical reasons: Different analysis systems can provide different results and serum cytokine concentrations are highly variable and depend on diurnal cycle, food intake, and other acute events.…”

Section: Discussioncontrasting

confidence: 76%

“… 16 As a measure for the disc degeneration of lumbar spine, we calculated a Pfirrmann score of the lumbar spine as sum of the Pfirrmann grades of L1/L2–L5/S1. 8 The score can have values between 5 and 25. We grouped them into two groups above and below the average: high Pfirrmann score: 14 and above, and low Pfirrmann score: 13 and below.…”

Section: Methodsmentioning

confidence: 99%

“…These studies 6 , 7 , 8 did not measure exactly the same markers, but for the markers measured in both studies, the data are conflicting. We found markers for collagen degradation (C4M, PRO‐C4, and PRO‐C3) to be elevated in the serum of 21 patients with any MC compared to 33 with noMC, and in 10 patients with cLBP and MC1 and 11 patients with MC2 compared to 19 patients with cLBP and noMC.…”

Section: Introductionmentioning

confidence: 99%

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Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes

Schulze,

Määttä,

Grad

et al. 2024

JOR Spine

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IntroductionModic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter‐observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow‐up would be of great value.MethodsWe used a highly sensitive and reproducible proteomics approach: DIA/SWATH‐MS to find serum biomarkers in a subset of the Northern Finland Birth Cohort 1966. Separately, we measured a panel of factors involved in inflammation and angiogenesis to confirm some potential biomarkers published before with an ELISA‐based method called V‐Plex.ResultsWe found neither an association between the serum concentrations of the proteins detected with DIA/SWATH‐MS with the presence of MC, nor a correlation with the size of the MC lesions. We did not find any association between the factors measured with the V‐Plex and the presence of MC or their size.ConclusionAltogether, our study suggests that a robust and generally usable biomarker to facilitate the diagnosis of MC cannot readily be found in serum.

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Section: Discussioncontrasting

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes

Schulze,

Määttä,

Grad

et al. 2024

JOR Spine

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Discogenic Low Back Pain: Anatomic and Pathophysiologic Characterization, Clinical Evaluation, Biomarkers, AI, and Treatment Options

De Simone,

Choucha,

Ciaglia

et al. 2024

JCM

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Discogenic low back pain (LBP) is a significant clinical condition arising from degeneration of the intervertebral disc, a common yet complex cause of chronic pain, defined by fissuring in the annulus fibrosus resulting in vascularization of growing granulation tissue and growth of nociceptive nerve fibers along the laceration area. This paper delves into the anatomical and pathophysiological underpinnings of discogenic LBP, emphasizing the role of intervertebral disc degeneration in the onset of pain. The pathogenesis is multifactorial, involving processes like mitochondrial dysfunction, accumulation of advanced glycation end products, and pyroptosis, all contributing to disc degeneration and subsequent pain. Despite its prevalence, diagnosing discogenic LBP is challenging due to the overlapping symptoms with other forms of LBP and the absence of definitive diagnostic criteria. Current diagnostic approaches include clinical evaluations, imaging techniques, and the exploration of potential biomarkers. Treatment strategies range from conservative management, such as physical therapy and pharmacological interventions, to more invasive procedures such as spinal injections and surgery. Emerging therapies targeting molecular pathways involved in disc degeneration are under investigation and hold potential for future clinical application. This paper highlights the necessity of a multidisciplinary approach combining clinical, imaging, and molecular data to enhance the accuracy of diagnosis and the effectiveness of treatment for discogenic LBP, ultimately aiming to improve patient outcomes.

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Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis

Cited by 2 publications

References 45 publications

Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes

Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes

Discogenic Low Back Pain: Anatomic and Pathophysiologic Characterization, Clinical Evaluation, Biomarkers, AI, and Treatment Options

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