Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair

PTPN22 and rheumatoid arthritis: Gratifying replication

“…Similar studies of RA have yielded evidence of monocyte activation (27,28) as well as other changes (29). It is currently unclear to what extent, if any, PTPN22 signaling pathways are reflected in these findings.…”

Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity

“…FCGR2A is a low-affinity Fc receptor (CD32) operating to fix complement, previously implicated in the pathogenesis of RA. 45 While these specific genes were not identified in previous studies, 18,19 they are involved in activation of the adaptive immune response, suggesting that patients with high ESR and RF levels may define one of the previously described FLS cell subpopulations.…”

“…18,19 Interestingly, Kasperkovitz et al 11 reported a correlation between an unique gene expression signature in a subset of RA FLS cell samples and the presence of a-smooth muscle actin (SMA) expressing myofibroblasts involved in wound healing. This population of a-SMA-positive cells was also reported in another study, 21 where these cells were identified in 50% of the RA patient tissues.…”

“…Previous studies have reported RA FLS cell gene expression heterogeneity. 11,18,19 Heterogeneity of gene expression is not surprising, given that RA is a complex inflammatory process that changes over time. Additionally, the clinical presentation of RA is heterogeneous and treatment outcomes vary.…”

Peripheral blood gene expression profiling in rheumatoid arthritis

“…20 Several groups have also examined gene expression profiles of PBMCs in a variety of autoimmune disorders, including SLE, 21,22 RA 20,23 and multiple sclerosis. 24 With the exception for SLE, 6 these studies have not revealed clear-cut expression 'signatures' of autoimmune disease.…”