Abstract:<div>
<div>
<div>
<p>Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role
in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells
including the benzothiadiazine-based anti-hypoglycemic diazoxide. Herein, we study the structure-activity
relationship of benzothiadiazine derivatives for CII inhibition for the first time. A number of more potent derivatives
were identified. Cy… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.