Discovery of ICOS‐Targeted Small Molecules Using Affinity Selection Mass Spectrometry Screening
Longfei Zhang,
Laura Calvo‐Barreiro,
Victor de Sousa Batista
et al.
Abstract:Inducible T cell co‐stimulator (ICOS) is a positive immune checkpoint receptor expressed on the surface of activated T cells, which could promote cell function after being stimulated with ICOS ligand (ICOS‐L). Although clinical benefits have been reported in the ICOS modulation‐based treatment for cancer and autoimmune disease, current modulators are restricted in biologics, whereas ICOS‐targeted small molecules are lacking. To fill this gap, we performed an affinity selection mass spectrometry (ASMS) screenin… Show more
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