Discovery of metal complexes with antibacterial properties in aqueous extracts of <i>Radix scutellariae</i> and a study of the antibacterial properties of the baicalin–manganese complex

Liu, Ya-Feng; Jiang, Chenxi; Peng, Liang; Li, Zhimin; Wang, Jintao; Liao, Xiangwen; Guo, Wenying

doi:10.1039/d3qi01034a

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…Among these, metal complexes are regarded as good photocatalysts with potential applications in drug delivery [37], environmental purification [38], and antibacterial processes [39]. Ligand-metal complexes have received increasing attention, owing to their unique structures, wide range of biological activities, diversity of substituents, and ease of synthesis [40].…”

Section: Introductionmentioning

confidence: 99%

Co–HOAT Complexes Change Their Antibacterial and Physicochemical Properties with Morphological Evolution

Xu,

Ding,

et al. 2024

Catalysts

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Antibacterial coordination compounds have attracted tremendous attention ascribed to their excellent designability. However, how the morphological evolution of these complexes influences their antibacterial and physicochemical properties has never been investigated based on proposed mechanisms. Thus, a series of Co–HOAT coordination compounds synthesized from inorganic to organic cobalt sources were prepared. We propose that with the same HOAT ligand, inorganic Co–HOAT nanosheets possess higher sterilization rates compared with organic Co–HOAT nanoparticles. This is explained by the different steric hindrance of cobalt sources. Relatively small steric hindrance could lead to ample active positions for inorganic cobalt ions to coordinate with both N and O atoms in HOAT. Meanwhile, organic Co2+ ions could only unite with N atoms in HOAT. Furthermore, by theoretical calculation, cobalt ions with adequate coordination sites are beneficial for developing nanosheet morphologies. Meanwhile, the Co–HOAT complexes with a lower density of electron clouds present higher sterilization rates due to the anchoring effect of electrostatic attraction. The proposed mechanism is that Co2+ released from compounds could cause multiple toxic effects to bacteria anchored by Co–HOATs. Finally, Co–HOATs’ behaviors have excellent antimicrobial properties without environmental limitations. In conclusion, the Co–HOATs appear to be a potential antibacterial catalyst in the antimicrobial field.

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Section: Introductionmentioning

confidence: 99%

Co–HOAT Complexes Change Their Antibacterial and Physicochemical Properties with Morphological Evolution

Xu,

Ding,

et al. 2024

Catalysts

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Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus

Meng,

Kang,

et al. 2024

FEBS Open Bio

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Methicillin‐resistant Staphylococcus aureus (MRSA) poses a challenge for clinical treatment and combining antibiotics with other agents might be a promising strategy to overcome this challenge. This study explored the synergistic antibacterial activity of baicalin (traditional Chinese medicine extract) and the narrow‐spectrum beta‐lactam antibiotic oxacillin sodium, both of which are poorly active against MRSA in vitro. The combination of baicalin and oxacillin sodium showed a synergistic effect with a fractional inhibitory concentration index of 0.5. Mechanistically, the supplementation of baicalin increased the permeability of bacterial cell walls and cell membranes, enhancing oxacillin sodium entry and bactericidal action. The combination of baicalin and oxacillin sodium also significantly inhibited MRSA USA300 biofilm formation by further reducing polysaccharide intercellular adhesion production. Therefore, the combination of baicalin and oxacillin sodium offers a new therapeutic option for addressing clinical MRSA resistance. Further studies, including clinical trials, will be required to validate the observed in vitro results.

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Aquifer pollution by metal-antibiotic complexes: Origins, transport dynamics, and ecological impacts

Baral,

Bhattarai,

Chaudhary

2024

Ecotoxicology and Environmental Safety

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Discovery of metal complexes with antibacterial properties in aqueous extracts of Radix scutellariae and a study of the antibacterial properties of the baicalin–manganese complex

Abstract: Antimicrobial resistance is a major public health concern. Many drug development strategies focus on metal complexes because they have different inhibitory mechanisms and are less prone to drug resistance than...

Cited by 6 publications

References 41 publications

Co–HOAT Complexes Change Their Antibacterial and Physicochemical Properties with Morphological Evolution

Co–HOAT Complexes Change Their Antibacterial and Physicochemical Properties with Morphological Evolution

Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus

Aquifer pollution by metal-antibiotic complexes: Origins, transport dynamics, and ecological impacts

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