Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones

Yogeeswari, Perumal; Menon, Niloufer; Semwal, Arvind; Muralidharan, Arjun; Sriram, Dharmarajan

doi:10.1016/j.ejmech.2011.04.021

Cited by 24 publications

(13 citation statements)

References 19 publications

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“…In contrast with the neglected diseases, the major part of CNS diseases affects people of all countries and economical classes. In this context, there are many efforts to develop novel drug candidates, for example: with hypnotic and sedative effects [ 105 ], as alternative for the treatment of neuropathic pain [ 106 ] and other analgesic effects [ 107 ].…”

Section: Central Nervous Systemmentioning

confidence: 99%

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

et al. 2011

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This review aims to highlight microwave-assisted organic synthesis as applied to medicinal chemistry in the last years, showing some reactions performed under microwave irradiation for the synthesis of distinct structurally molecules of biological interest, divided into the following groups: antineoplastics, anti-inflammatory, antimicrobial agents, antivirals, agents for the treatment of neglected diseases and central nervous system-acting prototypes.

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Section: Central Nervous Systemmentioning

confidence: 99%

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

et al. 2011

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“…Several small molecules like thiadiazole, triazole and oxadiazole based heterocycles have also been reported to possess potential bioactivity, including antiallergic, anticonvulsant, analgesic, anticancer, anti-microbial and antiinflammatory [6][7][8][9]. Thiosemicarbazides and their derivatives exhibit good biological activities such as anticancer [10], anti-HIV [11], antibacterial [12], antiviral [13] and antifungal [14]. The complexes of nitrogen and sulphur donor ligands are having a special and specific effect against the pathogens such as small pox virus, influenza, fungi and cancer [15].…”

Section: Introductionmentioning

confidence: 99%

in vitro Antimicrobial Activity and in silico Activity of 1-Thiocarbamoyl Substituted Pyrazole Derivatives

Chinnamanayakar¹,

Ezhilarasi²,

Prabha³

et al. 2018

Asian J. Chem.

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A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives (2a-2g) was carried out by the condensation reaction of (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones (1a-1g) with thiosemicarbazide, sodium hydroxide as a catalyst in the presence of ethanol as solvent. Further, (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones were synthesized by the Claisen-Schmidt condensation reaction of substituted aldehydes with 4-acetylbiphenyl in the presence of basic ethanolic solution. The structure of synthesized compounds were confirmed by FT-IR, 1 H NMR, 13 C NMR and 1 H-1 H COSY. The antimicrobial susceptibility tests of synthesized compounds were screened against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa. The docking studies also carried out by using 1UAG receptor for all the synthesized compounds (2a-2g).

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“…In a broader sense, the azo dyes constitute the largest diverse group of all the synthetic colorants [17]. In addition, hydrazones are the well known class of biologically and pharmacologically active compounds in the field of synthetic chemistry [18,19,20]. Some hydrazones have been introduced as potent drugs such as gyromitrin [21] used as a toxin and dihydralazine [22] used as a hypertensive drug.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectroscopic Properties of New Azo Dyes Derived from 3-Ethylthio-5-cyanomethyl-4-phenyl-1,2,4-triazole

et al. 2014

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New 1,2,4-triazole colorants were obtained, in high yields, by coupling 3-ethylthio-5-cyanomethyl-4-phenyl-1,2,4-triazole (1) with diazotized aniline derivatives 2, 4 and 6. The azo dyes prepared in this work may exist in three tautomeric forms. We found that the tautomerism is influenced mainly by the nature of substituent at the para position of the aniline coupling component. This tautomerisation was observed in the NMR spectra of the dyes. The dyes were characterized by IR, 1 H-NMR, 13 C-NMR and MS spectroscopic techniques.

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Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones

Cited by 24 publications

References 19 publications

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

in vitro Antimicrobial Activity and in silico Activity of 1-Thiocarbamoyl Substituted Pyrazole Derivatives

Synthesis and Spectroscopic Properties of New Azo Dyes Derived from 3-Ethylthio-5-cyanomethyl-4-phenyl-1,2,4-triazole

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