2023
DOI: 10.1021/acschembio.3c00402
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Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms

Jacqueline Plau,
Christopher E. Morgan,
Yuriy Fedorov
et al.

Abstract: The dysregulation of retinoid metabolism has been linked to prevalent ocular diseases including age-related macular degeneration and Stargardt disease. Modulating retinoid metabolism through pharmacological approaches holds promise for the treatment of these eye diseases. Cellular retinol-binding protein 1 (CRBP1) is the primary transporter of all-trans-retinol (atROL) in the eye, and its inhibition has recently been shown to protect mouse retinas from light-induced retinal damage. In this report, we employed … Show more

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Cited by 3 publications
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“…Most of these RBPs are intracellular proteins, and RBP4 is the only serum RBP and can transfer retinol from the liver to the peripheral tissue . In addition, almost all the inhibitors for RBPs are RBP4 inhibitors apart from the abnormal cannabidiol (Abn-CBD) and a series of recently reported inhibitors, which belong to CRBP1 inhibitors. , Therefore, research mainly focused on RBP4 inhibitors. Human RBP4 is a 21-kDa protein with 182 amino acid residues in a single chain that is encoded by a gene located on chromosome 10. The three-dimensional structure of RBP4 has been described above, and the β-barrel structure is responsible for retinol binding and transport in the aqueous environment .…”
Section: Rbpsmentioning
confidence: 99%
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“…Most of these RBPs are intracellular proteins, and RBP4 is the only serum RBP and can transfer retinol from the liver to the peripheral tissue . In addition, almost all the inhibitors for RBPs are RBP4 inhibitors apart from the abnormal cannabidiol (Abn-CBD) and a series of recently reported inhibitors, which belong to CRBP1 inhibitors. , Therefore, research mainly focused on RBP4 inhibitors. Human RBP4 is a 21-kDa protein with 182 amino acid residues in a single chain that is encoded by a gene located on chromosome 10. The three-dimensional structure of RBP4 has been described above, and the β-barrel structure is responsible for retinol binding and transport in the aqueous environment .…”
Section: Rbpsmentioning
confidence: 99%
“…), and the presence of hydrophobic, cyclic and bulky moieties contribute to the binding affinity. However, these inhibitors may lack selectivity over other RBPs since residues involved in hydrogen bonds are conserved among different CRBPs …”
Section: Rbpsmentioning
confidence: 99%