2024
DOI: 10.1021/acs.jafc.4c05989
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Discovery of Novel (5-Mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methyl Phenyl Carbamate as a Potent Phytoene Desaturase Inhibitor through Scaffold Hopping and Linker Modification

Di Zhang,
Chunxue Wang,
Yichi Zhang
et al.

Abstract: Phytoene desaturase (PDS) is a key rate-limiting enzyme in the carotenoid biosynthesis pathway. Although commercial PDS inhibitors have been developed for decades, it remains necessary to develop novel PDS inhibitors with higher bioactivity. In this work, we used the scaffold hopping and linker modification approaches to design and synthesize a series of compounds (7a−7o, 8a−8l, and 14a−14d). The postemergence application assay demonstrated that 8e and 7e separately showed the best herbicidal activity at 750 g… Show more

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