Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?

Li, Shengxian; Chu, Qianli; Ma, Junqing; Sun, Yun; Tao, Tao; Huang, Rong; Liu, Yu; Yue, Jiang; Zheng, Jun; Wang, Lihua; Xue, Xinli; Zhu, Mingyang; Kang, Xiaonan; Yin, Huiyong; Liu, Wei

doi:10.1210/jc.2016-2692

Cited by 45 publications

(48 citation statements)

References 55 publications

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“…There are also contrary studies demonstrating that vitamin D supplementation (100,000 IU loading dose, followed by 20,000 IU/week) did not improve CVD risk factors including blood pressure, lipid profiles and glucose metabolism parameters in vitamin D insufficient population [ 36 ]. Current evidence suggested that increased insulin and androgens levels may negatively influence lipid profiles in women with PCOS [ 37 ]. Fatty acids byproducts have an important role in inflammation and reproduction [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

Dastorani

Aghadavod

Mirhosseini

et al. 2018

Reprod Biol Endocrinol

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BackgroundVitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It is hypothesized that vitamin D supplementation influences metabolic profile of these patients and indirectly might affect fertility and the outcomes. Therefore, this study was conducted to determine the effects of vitamin D supplementation on the levels of anti-Müllerian hormone (AMH), metabolic profiles, and gene expression of insulin and lipid metabolism in infertile women with PCOS who were candidate for in vitro fertilization (IVF).MethodsThis study was a randomized, double-blinded, placebo-controlled trial conducted among 40 infertile women, aged 18–40 years, diagnosed with PCOS and was candidate for IVF. Participants were randomly assigned into two intervention groups for receiving either 50,000 IU vitamin D or placebo (n = 20 each group) every other week for 8 weeks. Gene expression for insulin and lipid metabolism was conducted using peripheral blood mononuclear cells (PBMCs) of women with PCOS, via RT-PCR method.ResultsVitamin D supplementation led to a significant reduction in serum AMH (− 0.7 ± 1.2 vs. − 0.1 ± 0.5 ng/mL, P = 0.02), insulin levels (− 1.4 ± 1.6 vs. -0.3 ± 0.9 μIU/mL, P = 0.007), homeostatic model of assessment for insulin resistance (− 0.3 ± 0.3 vs. -0.1 ± 0.2, P = 0.008), and a significant increase in quantitative insulin sensitivity check index (+ 0.009 ± 0.01 vs. + 0.001 ± 0.004, P = 0.04), compared with the placebo. Moreover, following vitamin D supplementation there was a significant decrease in serum total- (− 5.1 ± 12.6 vs. + 2.9 ± 10.9 mg/dL, P = 0.03) and LDL-cholesterol levels (− 4.5 ± 10.3 vs. + 2.5 ± 10.6 mg/dL, P = 0.04) compared with the placebo.ConclusionOverall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels.Trial registrationThis study was retrospectively registered in the Iranian website (www.irct.ir) for clinical trials registration (http://www.irct.ir: IRCT20170513033941N27).

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Section: Discussionmentioning

confidence: 99%

The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

Dastorani

Aghadavod

Mirhosseini

et al. 2018

Reprod Biol Endocrinol

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“…It has been estimated that at least one abnormal lipid parameter is found in 70% of obese women with PCOS (Legro et al, 2001), which is most probably due to IR (Robinson et al, 1996). Insulin and androgens levels in blood may have opposing effects on lipid profiles in PCOS patients (Li et al, 2016). Brothers of women with PCOS have significantly higher total and LDL cholesterol as well as triglyceride levels, and IR (Sam et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Increased insulin resistance in men with unexplained infertility

Mansour

El-Faissal

Kamel

et al. 2017

Reproductive BioMedicine Online

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This prospective case-control study aimed to test the presence of insulin resistance (IR) in men with unexplained infertility. We included two groups: the study group including 160 infertile men with unexplained oligozoospermia (sperm count <10 × 10/ml) and normal hormonal profile, and the control group of 79 men with proven fertility within the preceding year. A fasting blood test measured IR, FSH, LH, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides. Insulin level was significantly higher in the study group (13.67 ± 10.44) compared with the control group (5.46 ± 3.15), P < 0.0001, and IR was significantly higher in the study group, P < 0.0001. FSH was significantly (P < 0.0001) higher in the study group (4.71 ± 2.57) than the control group (3.15 ± 1.92). LH was significantly higher in the study group (4.98 ± 2.41) compared with the control group (3.15 ± 1.12), P < 0.0001. Total cholesterol was significantly higher in the study group (198.29 ± 37.52) than the control group (182.45 ± 35.92), P < 0.05. In conclusion, IR in men with unexplained infertility may be a cause of reproductive and metabolic abnormalities. The benefit of insulin-sensitizing agents for these patients should be tested.

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“…29 A recent study reported that insulin and androgens may have opposing effects on lipid profiles in women with PCOS, with changes in the production of phospholipids, free fatty acids, and bioactive lipids. 30 Studies have also found evidence for endothelial dysfunction in women with PCOS, matched for BMI. 31,32 Furthermore, coronary artery calcification is associated with PCOS with odds ratios ranging from 2.3 to 2.4.…”

Section: Metabolic Syndromementioning

confidence: 99%

A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines

et al. 2018

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Polycystic ovary syndrome (PCOS) is a common hormonal condition with reproductive, metabolic, and psychological sequelae. The Rotterdam Criteria are now internationally accepted, with different phenotypes recognized with varying clinical presentations and risk profiles. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications and management strategies. PCOS remains underdiagnosed and women experience significant delays to diagnosis. Effective dissemination of evidence-based management is therefore vital. In this review, we summarize key aspects of PCOS as a prelude to this issue of on PCOS which focuses on the development of the international evidence-based guideline on the assessment and management of PCOS and the related translation program. We cover diagnostic criteria, prevalence, phenotypes, reproductive, metabolic, and psychological factors of PCOS. We also cover management strategies including lifestyle interventions as well as treatment of nonreproductive outcomes and reproductive outcomes informed by the latest international evidence-based guidelines.

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Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?

Abstract: We found serum lipid profiles changed in women with PCOS. Obesity and compensatory hyperinsulinemia promoted the metabolism of arachidonic acid and other PUFAs, whereas androgen had an inhibitory effect.

Cited by 45 publications

References 55 publications

The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

Increased insulin resistance in men with unexplained infertility

A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines

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