Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis
Zihan Shi,
Xianyan Liu,
Shuohan Wu
et al.
Abstract:Liver fibrosis is a condition characterized by aberrant
proliferation
of connective tissue in the liver resulting from diverse etiological
factors. G protein-coupled receptor GPR55 has recently been identified
as a regulator of liver diseases. Herein, we report the discovery
of a cyclic peptide P1-1 that antagonizes GPR55 and suppresses collagen
secretion in hepatic stellate cells. The alanine scanning and docking
study was carried out to predict the binding mode and allowed for
further structural optimization… Show more
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