Discovery of Novel Phenoxypyridine as Promising Protoporphyrinogen Ix Oxidase Inhibitors

Inhibition profile of trifludimoxazin towards PPO2 target site mutations

“…1 As a complement to investigating new targets and new chemical motifs, researchers explore known chemical motifs by using molecular variations and combinations of chemical scaffolds for a known target. [2][3][4][5] One prominent example is protoporphyrinogen IX oxidase (PPO), the last shared enzyme of chlorophyll and heme biosynthesis in tetrapyrrole biosynthesis.…”

“…Theoretically, hundreds of targets for herbicides that affect the growth and development of plants exist, yet the number of targets of commercial relevance for herbicide products is limited, as shown in Herbicide Resistance Action Committee (HRAC’s) mode of action and chemistry overview poster 1 . As a complement to investigating new targets and new chemical motifs, researchers explore known chemical motifs by using molecular variations and combinations of chemical scaffolds for a known target 2‐5 . One prominent example is protoporphyrinogen IX oxidase (PPO), the last shared enzyme of chlorophyll and heme biosynthesis in tetrapyrrole biosynthesis.…”

“…The PPO enzyme is a particularly good target with respect to druggability. Structurally diverse chemistry classes are still being identified, allowing the synthesis of many new inhibitors 2–4 . The first PPO inhibitor, nitrofen, was introduced onto the market in 1964.…”

“…Structurally diverse chemistry classes are still being identified, allowing the synthesis of many new inhibitors. [2][3][4] The first PPO inhibitor, nitrofen, was introduced onto the market in 1964. Despite more than half a century of chemical synthesis leading to thousands of synthesized molecules, PPO active ingredients with new characteristics can still be found.…”