Discovery of novel pleuromutilin derivatives as potent antibacterial agents

Zhou, Yuhang; Yi, Yunpeng; Wang, Jiangkun; Zheng, Yufeng; Liu, Qinqin; Pu, Wanxia; Shang, Ruofeng

doi:10.1016/j.ejmech.2022.114403

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…reported Lumacaftor, Dihydroergocornine, and Olaparib as potent molecules for S. aureus FemX [15] . Pyrimidine moieties compounds showed the higher antibacterial activity than 3,4‐dihydropyrimidin against S. aureus [16] …”

Section: Discussionmentioning

confidence: 99%

“…Pyrimidine moieties compounds showed the higher antibacterial activity than 3,4-dihydropyrimidin against S. aureus. [16] In S. aureus, FemC has been reported as a methicillin resistance factor and it regulates the peptidoglycan synthesis. [6c,17] Here, in this study, in silico methods such as virtual screening, molecular docking, and molecular dynamics have been used to screen the potent molecules against FemC of S. aureus.…”

Section: Chemistryselectmentioning

confidence: 99%

“…[15] Novel synthesized pleuromutillin derivatives exhibiting 3,4-dihydropyrimidin and pyrimidine moieties showed ED 50 = 16.14 mg/ kg. [16] These synthesized compounds exhibited non-covalent interactions with peptidyl transferase center (PTC) domain of ribosome of S. aureus.…”

Section: Introductionmentioning

confidence: 99%

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Screening and Identification of Natural Product‐Like Compounds as Potential Antibacterial Agents Targeting FemC of Staphylococcus aureus: An in‐Silico Approach

Dalal

Kumari

2022

ChemistrySelect

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FemC is a methicillin resistance factor and regulates the synthesis of peptidoglycan in Staphylococcus aureus. Here, a set of natural product‐like compounds from Enamine and Selleckchem databases were screened at the active site of validated FemC model. Molecules that had interactions and good binding energies with protein were filtered by pharmacokinetic and ADMET properties. Molecular docking and molecular dynamics (MD) analysis displayed the identified molecules had stable and static interactions with FemC to form stable FemC‐inhibitor(s) complexes. Molecular Mechanics/Poisson‐Boltzmann Surface Area (MMPBSA) confirmed that identified molecules interacted with S15, M16, S17, R31, R43, Q47, K48, and R49 of FemC and resulted in the formation of lower energy complexes. The current study, hereby, reported the four (S4958 Glycocholic acid, SP‐146, Hupehenine, and Limonin) potent natural product‐like compounds that are required to be validated and may be further utilized to develop novel scaffolds for antimicrobials against S. aureus.

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Section: Discussionmentioning

confidence: 99%

Section: Chemistryselectmentioning

confidence: 99%

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Screening and Identification of Natural Product‐Like Compounds as Potential Antibacterial Agents Targeting FemC of Staphylococcus aureus: An in‐Silico Approach

Dalal

Kumari

2022

ChemistrySelect

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“…Patients with diabetes often suffer from slow wound repair and exhibit diabetic foot ulcers. H19 promotes wound healing in diabetic conditions 98 . Experimental evidence showed that sEV H19 derived from adipose mesenchymal stem cells (ADSCs) accelerates wound healing in diabetic mice, and silencing H19 in ADSCs decreased H19 accumulation in sEV, which inhibited skin fibroblast proliferation, migration and invasion by targeting miR‐19b/SOX9 83 .…”

Section: Roles Of Sev Lncrnas In Diabetesmentioning

confidence: 99%

“…H19 promotes wound healing in diabetic conditions. 98 Experimental evidence showed that sEV H19 derived from adipose mesenchymal stem cells (ADSCs) accelerates wound healing in diabetic mice, and silencing H19 in ADSCs decreased H19 accumulation in sEV, which inhibited skin fibroblast proliferation, migration and invasion by targeting miR‐19b/SOX9. 83 Overexpression of H19 in MSC‐derived sEV promotes wound healing in diabetic foot ulcers by sponging miRNA‐152‐3p, thereafter upregulating phosphatase and tensin homolog (PTEN), a regulator of cell proliferation and growth 84 (Table 2 ).…”

Section: Roles Of Sev Lncrnas In Diabetesmentioning

confidence: 99%

Roles of long noncoding RNAs and small extracellular vesicle‐long noncoding RNAs in type 2 diabetes

Chang

Wang

Zhang

et al. 2022

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The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small extracellular vesicles (sEV) were shown to mediate communication between organs and participate in diabetes progression. Some sEV lncRNAs derived from stem cells are being developed as potential therapeutic agents for diabetic complications. In this review, we summarize the current knowledge relating to lncRNA biogenesis, the mechanisms of lncRNA sorting into sEV and the regulatory roles of lncRNAs and sEV lncRNAs in diabetes. Knowledge of lncRNAs and sEV lncRNAs in diabetes will aid in the development of new therapeutic drugs for T2D in the future.

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