Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Fadaly, Wael A.A.; Nemr, Mohamed T.M.; Kahk, Nesma M.

doi:10.1016/j.bioorg.2024.107403

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2024.107403

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Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Wael A.A. Fadaly,

Mohamed T.M. Nemr,

Nesma M. Kahk

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Cited by 12 publications

References 89 publications

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New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

Ketha,

Sudhakar,

Kethireddy

et al. 2024

Chemistry & Biodiversity

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Chalcone‐incorporated pyridine‐pyrimidines i.e. derivatives of (5‐(6‐(pyrimidin‐5‐yl)pyridin‐3‐yl)thiophen‐2‐yl)prop‐2‐en‐1‐one were synthesized and their structures were confirmed by analytical techniques. In addition, all the derivatives were examined for their capacity to fight against cancer towards four cell lines, including breast (MCF‐7), prostate (DU‐145 and PC3), and lung (A549) by utilizing the MTT technique and the clinically used chemotherapy medication, etoposide serving as a positive reference. All these results were expressed in IC50 µM, and values of synthesized compounds are compared with a reference drug, showing values ranging from 1.97 ± 0.45 µM to 3.08 ± 0.135 µM. Among those, a few compounds 10(a‐e) demonstrated strong activities with corresponding cell lines.

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New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

Ketha,

Sudhakar,

Kethireddy

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1

Xu,

Li,

et al. 2024

Mol Divers

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Synthesis, biological activities and mechanistic studies of C20-ketone pachysandra alkaloids as anti-hepatocellular carcinoma agents

Zhao,

Bai,

et al. 2024

Mol Divers

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Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Cited by 12 publications

References 89 publications

New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1

Synthesis, biological activities and mechanistic studies of C20-ketone pachysandra alkaloids as anti-hepatocellular carcinoma agents

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