Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships

Crystal structure of 2-methoxy-N'-(3,5-dichloro-2- hydroxybenzylidene)benzohydrazide, C15H12Cl2N2O3

“…Hydrazone derivatives have been widely investigated for their biological activity [2][3][4][5]. Recently, the crystal structures of a number of hydrazone derivatives have been reported [6][7][8][9].…”

4-Fluoro-N'-(2-hydroxy-3-methoxybenzylidene) benzohydrazide and its Oxidovanadium(V) Complex: Syntheses, Crystal Structures and Insulin-enhancing Activity

“…14,15 Schiff bases with hydrazone type are of particular interest due to their biological properties. [16][17][18][19][20] In recent years, a number of vanadium complexes were prepared from tridentate hydrazones, because of their excellent coordination ability and facilitate preparation. In view of the increasing importance of vanadium complexes with hydrazone type Schiff bases, we report herein the synthesis, characterization, and insulin-enhancing activity of a novel oxidovanadium(V) complex with the hydrazone compound 4-fluoro-N'-(2-hy-droxy-3-methoxybenzylidene)benzohydrazide monohydrate (H 2 L · H 2 O; Scheme 1) and maltol analogous compound kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka; Scheme 1).…”

Untitled

“…[1][2][3][4][5][6][7][8][9] Among all the heterocyclic derivatives, the class of multicycle compounds bearing thienopyrimidine nucleus exhibit a diversity of pharmacological effects such as antibacterial, antifungal, kinase inhibition, immunosuppressive, antidiabetic and anticancer activity .Up to now, there are many different structures containing thienopyrimidine nucleus have been synthesized and evaluated for biological activities. [10][11][12][13][14][15][16][17] Similarly, the Shiff bases have also been reported to possess an array of biological activities namely antimicrobial, ulcerogenic, anti HIV, anticonvulsant, and CNS depressant activities [18][19][20][21] The promising bioactive diversity of these class of heterocyclic compounds and Schiff bases urged us to synthesize and biologically evaluate a series of novel structural variants of thieno [2, 3-d] pyrimidinone derivatives. We have synthesized and utilized 3-amino 2-methyl 4, 5-tetramethylene thieno [2, 3-d] pyrimidin (3H)-4-one as key prototype structural unit, and treated the 3-active amino group with substituted aryl aldehydes to get a new series of Schiff bases.…”