Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling

Mera, Wafa A.; Alzihlif, Malek; Taha, Mutasem O.; Khanfar, Mohammad A.

doi:10.2174/1871520616666160926114416

ACAMC

2017

DOI: 10.2174/1871520616666160926114416

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Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling

Wafa A. Mera¹,

Malek Alzihlif²,

Mutasem O. Taha

et al.

Abstract: Our efforts culminated in the identification of potent BTK ligands having desired inhibitory activities and structurally distinct from known active reference compounds (i.e., training compounds) and represent new chemotypes.

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Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses

Khanfar

Alqtaishat

2019

Computational Biology and Chemistry

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Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling

Abstract: Our efforts culminated in the identification of potent BTK ligands having desired inhibitory activities and structurally distinct from known active reference compounds (i.e., training compounds) and represent new chemotypes.

Cited by 4 publications

References 0 publications

Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses

Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses

Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor

Discovery of novel Flt3 inhibitory chemotypes through extensive ligand-based and new structure-based pharmacophore modelling methods

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