Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

Baillache, Daniel J.; Valero, Teresa; Lorente-Macías, Álvaro; Bennett, David Jonathan; Elliott, Richard J. R.; Carragher, Neil O.; Unciti-Broceta, Asier

doi:10.1039/d3md00454f

RSC Med. Chem.

2023

DOI: 10.1039/d3md00454f

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Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

Daniel J. Baillache,

Teresa Valero,

Álvaro Lorente-Macías

et al.

Abstract: Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer in adults, with an average life expectancy under treatment of approx. 15 months. GBM is characterised by a complex...

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Cited by 3 publications

References 48 publications

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Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells

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Discerning potent CSF-1r inhibitors for targeting and therapy of neuroinflammation using computational approaches

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Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

Abstract: Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer in adults, with an average life expectancy under treatment of approx. 15 months. GBM is characterised by a complex...

Cited by 3 publications

References 48 publications

Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells

Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells

Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

Discerning potent CSF-1r inhibitors for targeting and therapy of neuroinflammation using computational approaches

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