Discovery of quinolinequinones with N-phenylpiperazine by conversion of hydroxyquinoline as a new class of antimicrobial agents targeting resistant pathogenic microorganisms

Yıldız, Mahmut; Bayrak, Nilüfer; Yıldırım, Hatice; Çakmak, Selin Melis; Yilmaz, Fatima Nur; Mataracı-Kara, Emel; Shilkar, Deepak; Jayaprakash, Venkatesan; Tuyun, Amaç Fatih

doi:10.1016/j.bioorg.2022.106045

Cited by 2 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its biosynthetic pathway has also been proposed by Wang et al 39 Overall, our findings from this review may provide new insights for the further development of novel quinoline-based drug molecules for the treatment of various disorders. [40][41][42][43][44][45][46] Challenges and Future Prospects for Streptonigrin in New Drug Design,…”

Section: Dovepress 1073mentioning

confidence: 99%

Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy

Nasir¹,

Sekar²,

Ravi³

et al. 2023

DDDT

View full text Add to dashboard Cite

Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It was previously used as an anticancer drug but has been discontinued because of its toxic effects. However, according to the most recent studies, the toxicity of streptonigrin and its structurally modified derivatives has been reduced while maintaining their potential pharmacological action at lower concentrations. To date, many investigations have been conducted on this molecule and its derivatives to determine the most effective molecule with low toxicity to enable new drug discovery. Therefore, the main objective of this study is to provide a comprehensive review and to discuss the prospects for streptonigrin and its derived compounds, which may boost the molecule as a highly interesting target molecule for new drug design, development and therapy. To complete this review, relevant literature was collected from several scientific databases, including Google Scholar, PubMed, Scopus and ScienceDirect. Following a complete screening, the obtained information is summarized in the present review to provide a good reference and accelerate the development and utilization of streptonigrin and its derivatives as pharmaceuticals.

show abstract