Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Li, Chong; He, Kui; Xie, Xiaoming; Yang, Jiju; Zhang, Fan; Yang, Yue; Hao, Huifeng; Zhao, Shaokun; Li, Xin; Tian, Guihua

doi:10.1007/s11684-023-0989-7

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Functional magnetic resonance imaging (MRI) data support that areas of brain activity in migraine patients who undergo acupuncture include the limbic system and the default mode network, as well as pain processing areas. The increased ALFF (Amplitude of Low-Frequency Fluctuation) values in these areas suggest that acupuncture may enhance spontaneous brain activity in patients with migraines ( 49 ). Acupuncture has been shown to be superior to sham surgery and placebo ( 68 , 69 ).…”

Section: Applications and Research Evidences Of Cat In Migraine Manag...mentioning

confidence: 99%

“…Current diagnostic criteria do not adequately capture the heterogeneity of migraine, including underlying genetic and neurobiological factors. For example, a controlled trial of acupuncture treatment was unable to hypothesize a link between psychological and pain states because the Psychological Assessment Scale lacked an assessment of pain states ( 49 ). In addition, a recent meta-analysis showed a trend toward higher placebo responses in migraine prevention trials over the last 30 years ( 72 ).…”

Section: Limitations Of Research On the Use Of Cat For Migraine Treat...mentioning

confidence: 99%

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New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies

Song,

Zhu,

et al. 2024

Front. Neurol.

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Migraine is a prevalent and disabling neurovascular disorder, with women being more susceptible, characterized by unilateral throbbing headache, often accompanied by nausea and vomiting, and often associated with various comorbidities such as brain and cardiovascular diseases, which can have a serious impact on quality of life. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the main first-line medications for the treatment of pain, long-term use often leads to side effects and drug addiction, which emphasizes the need to investigate alternative pain management strategies with fewer adverse effects. Complementary and alternative medicine is a viable pain intervention often used in conjunction with traditional medications, including acupuncture, herbs, moxibustion, transcutaneous electrical stimulation, bio-supplements, and acupressure, which offer non-pharmacological alternatives that are now viable pain management options. This review focuses on the mechanistic doctrine of migraine generation and the role and potential mechanisms of Complementary and Alternative Therapies (CAT) in the treatment of migraine, summarizes the research evidences for CAT as an adjunct or alternative to conventional therapies for migraine, and focuses on the potential of novel migraine therapies (calcitonin gene-related peptide (CGRP) antagonists and pituitary adenylyl cyclase-activating peptide (PACAP) antagonists) with the aim of evaluating CAT therapies as adjunctive or alternative therapies to conventional migraine treatment, thereby providing a broader perspective on migraine management and the design of treatment programs for more effective pain management.

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Section: Applications and Research Evidences Of Cat In Migraine Manag...mentioning

confidence: 99%

Section: Limitations Of Research On the Use Of Cat For Migraine Treat...mentioning

confidence: 99%

New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies

Song,

Zhu,

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis

Lee,

Kwon,

Lee

et al. 2024

Front. Med.

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Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study

Yin,

Bao,

et al. 2025

Complementary Therapies in Medicine

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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Cited by 5 publications

References 26 publications

New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies

New perspectives on migraine treatment: a review of the mechanisms and effects of complementary and alternative therapies

Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis

Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study

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