Please cite this article as: Elrazaz EZ, Serya RAT, Ismail NSM, Abou El Ella DA, Abouzid KAM, Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents, Future Journal of Pharmaceutical sciences (2015),
AbstractThienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored fortheir inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure-activity relationships of thieno[2,3-d]pyrimidines derivatives reported to date.