2014
DOI: 10.1016/j.bmcl.2014.04.058
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Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors

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Cited by 25 publications
(14 citation statements)
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“…[44,45,46] In 2014, Park et al [47]designed thienopyrimidine-based analoguesthrough modification of the known IKKβ inhibitor, SPC-839, and then biologically evaluated them.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…[44,45,46] In 2014, Park et al [47]designed thienopyrimidine-based analoguesthrough modification of the known IKKβ inhibitor, SPC-839, and then biologically evaluated them.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…Most of the synthesized anticancer compounds have an heterocyclic core derivatized from pyrimidine, and many of them are thienopyrimidines. Interestingly, they have recently been investigated as scaffolds for protein kinase (PKs) inhibitors [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Research group of Han disclosed the synthetic route of thienopyrimidine analogs which were found to be effective FLT3 inhibitors [33]. Standard conditions to carry out this protocol started from the Knoevenagel condensation Scheme Sandmeyer reaction for the preparation of aminopyrimidines derivatives Scheme 5 Preparation of arylpiperazines using Sandmeyer reaction as key step of 2-acetylthiophene 27 with malononitrile 28 followed by the treatment with elemental sulfur to obtain corresponding thiophene, ready to produce thienopyrimidine 29 after treatment with formamide.…”
Section: Chlorination Via Sandmeyer Reactionmentioning
confidence: 99%