Discovery of trans-3,4,4′-trihydroxystilbene as new lead vasorelaxant agent for antihypertensive drug development

Loh, Yean Chun; Chan, Sock Ying; Oo, Chuan Wei; Yam, Mun Fei

doi:10.1016/j.lfs.2021.119560

Cited by 1 publication

(2 citation statements)

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“…M3 muscarinic acetylcholine receptor has been reported to be associated with the regulation of BP and hypertension. 32 , 33 Razzaq and associates 34 found that pulegone prevented hypertension through activation of muscarinic receptors and cyclooxygenase pathway in L‐NAME‐induced hypertensive rats. Deng and associates 35 showed that eliminating M3R signaling reduced BP in DSS rats.…”

Section: Discussionmentioning

confidence: 99%

“…From the 4th week after conception, a muscarinic response to acetylcholine can be detected. M3 muscarinic acetylcholine receptor has been reported to be associated with the regulation of BP and hypertension 32,33 . Razzaq and associates 34 found that pulegone prevented hypertension through activation of muscarinic receptors and cyclooxygenase pathway in L‐NAME‐induced hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

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Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

Zhang,

Yao,

Bao

et al. 2023

J of Clinical Hypertension

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Recent studies have reported the role of the M3 muscarinic acetylcholine receptor (M3R), a member of the G‐protein coupled receptor superfamily, encoded by the CHRM3 gene, in cardiac function and the regulation of blood pressure (BP). The aim of this study was to investigate the associations of CHRM3 genetic variants with salt sensitivity, longitudinal BP changes, and the development of hypertension in a Chinese population. We conducted a chronic dietary salt intervention experiment in a previously established Chinese cohort to analyze salt sensitivity of BP. Additionally, a 14‐year follow‐up was conducted on all participants in the cohort to evaluate the associations of CHRM3 polymorphisms with longitudinal BP changes, as well as the incidence of hypertension. The single nucleotide polymorphism (SNP) rs10802811 within the CHRM3 gene displayed significant associations with low salt‐induced changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), while rs373288072, rs114677844, and rs663148 exhibited significant associations with SBP and MAP responses to a high‐salt diet. Furthermore, the SNP rs58359377 was associated with changes in SBP and pulse pressure (PP) over the course of 14 years. Additionally, the 14‐year follow‐up revealed a significant association between the rs619288 polymorphism and an increased risk of hypertension (OR = 1.74, 95% CI: 1.06‐2.87, p = .029). This study provides evidence that CHRM3 may have a role in salt sensitivity, BP progression, and the development of hypertension.

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