Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway

Han, Haoyi; Alsayed, Ali Mohammed Mohammed; Wang, Yi; Yan, Qi; Shen, Ancheng; Zhang, Jianxia; Ye, Yanfei; Liu, Zhiguo; Wang, Kun; Zheng, Xiaohui

doi:10.1016/j.bioorg.2023.106358

Cited by 9 publications

(1 citation statement)

References 36 publications

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“…We invite future studies to corroborate our results and replicate our analysis with data from other centers, not only from Asia and Europe but also from Africa and America. A molecular analysis studying the underlying reason why sarcopenia is harming survival and what factors per region change the association are needed and could aid ongoing preclinical efforts to identify novel targets to treat HCC 41 – 43 . Furthermore, future randomized controlled trials are best equipped to investigate if interventions to increase muscle mass in sarcopenic patients lower their risk of serious complications and improve survival.…”

Section: Discussionmentioning

confidence: 99%

Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts

Beumer

Takagi

Buettner

et al. 2023

International Journal of Surgery

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Background: Patient fitness is important for guiding treatment. Muscle mass, as a reflection thereof, can be objectively measured. However, the role of East–West differences remains unclear. Therefore, we compared the impact of muscle mass on clinical outcomes after liver resection for hepatocellular carcinoma (HCC) in a Dutch [the Netherlands (NL)] and Japanese [Japan (JP)] setting and evaluated the predictive performance of different cutoff values for sarcopenia. Method: In this multicenter retrospective cohort study, patients with HCC undergoing liver resection were included. The skeletal muscle mass index (SMI) was determined on computed tomography scans obtained within 3 months before surgery. The primary outcome measure was overall survival (OS). Secondary outcome measures were: 90-day mortality, severe complications, length of stay, and recurrence-free survival. The predictive performance of several sarcopenia cutoff values was studied using the concordance index (C-index) and area under the curve. Interaction terms were used to study the geographic effect modification of muscle mass. Results: Demographics differed between NL and JP. Gender, age, and body mass index were associated with SMI. Significant effect modification between NL and JP was found for BMI. The predictive performance of sarcopenia for both short-term and long-term outcomes was higher in JP compared to NL (maximum C-index: 0.58 vs. 0.55, respectively). However, differences between cutoff values were small. For the association between sarcopenia and OS, a strong association was found in JP [hazard ratio (HR) 2.00, 95% CI [1.230–3.08], P=0.002], where this was not found in NL (0.76 [0.42–1.36], P=0.351). The interaction term confirmed that this difference was significant (HR 0.37, 95% CI [0.19–0.73], P=0.005). Conclusions: The impact of sarcopenia on survival differs between the East and West. Clinical trials and treatment guidelines using sarcopenia for risk stratification should be validated in race-dependent populations prior to clinical adoption.

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Section: Discussionmentioning

confidence: 99%

Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts

Beumer

Takagi

Buettner

et al. 2023

International Journal of Surgery

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Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014–2024) review

Nagargoje,

Deshmukh,

Shaikh

et al. 2024

Archiv der Pharmazie

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Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure–activity relationship (SAR), and in silico molecular docking studies.

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Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers

Pan,

Yang,

et al. 2024

Med Chem Res

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Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway

Cited by 9 publications

References 36 publications

Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts

Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts

Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014–2024) review

Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers

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