2016
DOI: 10.1002/ejp.892
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Discrepancies between cortical and behavioural long‐term readouts of hyperalgesia in awake freely moving rats

Abstract: BackgroundIt is still unclear to what extent the most common animal models of pain and analgesia, based on indirect measures such as nocifensive behaviours, provide valid measures of pain perception.MethodsTo address this issue, we developed a novel animal model comprising a more direct readout via chronically (>1 month) implanted multichannel electrodes (MCE) in rat primary somatosensory cortex (S1; known to be involved in pain perception in humans) and compared this readout to commonly used behavioural pain‐… Show more

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Cited by 6 publications
(17 citation statements)
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“…The same IOIs were used for the analysis of the evoked FP. The resulting IOIs were consistent with previously reported IOIs (45,48,79).…”
Section: Extracted Evoked Responsessupporting
confidence: 91%
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“…The same IOIs were used for the analysis of the evoked FP. The resulting IOIs were consistent with previously reported IOIs (45,48,79).…”
Section: Extracted Evoked Responsessupporting
confidence: 91%
“…To clarify whether stimulation with the selected microelectrodes not only affects nociceptive motor behavior, we also assessed the effects on nociceptive-evoked activity in the hind and forepaw S1 cortices ( 45 , 46 , 48 ) in the same animals during weeks 4 to 5 PS. As shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…In databases of scientific data there has previously typically been a trade off between organization of data and performance in terms of data write and read rates for larger data sets. Relational data bases, at the very end of the spectrum with regard to organizational capabilities with extensive support for complex relationships between data, have been used by many research groups for storing scientific data, also recently for storing larger files such as images, movies and also electrophysiological data (Ljungquist et al 2011 ; Ljungquist et al 2016 ). However, if storing data values as single data entries in the data base, performance drops quickly, as INSERT statements in relational databases are costly (Schwartz et al 2012 ).…”
Section: Discussionmentioning
confidence: 99%