Discrepancies Between Nomenclature and Indications of Psychotropics

Minami, Fusaka; Zohar, Joseph; Suzuki, Takefumi; Koizumi, Teruki; Mimura, Masaru; Yagi, Gohei; Uchida, Hiroyuki

doi:10.1055/a-0626-7135

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…It is suggested that amisulpride and cariprazine have greater D 2 /D 3 -receptor antagonism with a similar serotonergic profile to the clozapine-like drugs. Amisulpride is a potent 5-HT 7 -receptor antagonist, whereas cariprazine is a 5-HT 2B -receptor antagonist and a 5-HT 1A -receptor partial agonist [ 50 , 51 ].…”

Section: Antipsychotics Overview/classesmentioning

confidence: 99%

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Edinoff

Sathivadivel

McNeil

et al. 2022

Neurology International

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Pregnant women constitute a vulnerable population, with 25.3% of pregnant women classified as suffering from a psychiatric disorder. Since childbearing age typically aligns with the onset of mental health disorders, it is of utmost importance to consider the effects that antipsychotic drugs have on pregnant women and their developing fetus. However, the induction of pharmacological treatment during pregnancy may pose significant risks to the developing fetus. Antipsychotics are typically introduced when the nonpharmacologic approaches fail to produce desired effects or when the risks outweigh the benefits from continuing without treatment or the risks from exposing the fetus to medication. Early studies of pregnant women with schizophrenia showed an increase in perinatal malformations and deaths among their newborns. Similar to schizophrenia, women with bipolar disorder have an increased risk of relapse in antepartum and postpartum periods. It is known that antipsychotic medications can readily cross the placenta, and exposure to antipsychotic medication during pregnancy is associated with potential teratogenicity. Potential risks associated with antipsychotic use in pregnant women include congenital abnormalities, preterm birth, and metabolic disturbance, which could potentially lead to abnormal fetal growth. The complex decision-making process for treating psychosis in pregnant women must evaluate the risks and benefits of antipsychotic drugs.

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Section: Antipsychotics Overview/classesmentioning

confidence: 99%

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

Edinoff

Sathivadivel

McNeil

et al. 2022

Neurology International

View full text Add to dashboard Cite

show abstract

“…They prescribe ‘antidepressants’ for anxiety disorders and ‘antipsychotics’ for depression. Indeed, we recently reported on a significant gap between the generic terminology of ‘antipsychotics’ and ‘antidepressants’ and their actual approved indications . In general, more than half of ‘second‐generation antipsychotics’ and ‘newer antidepressants’ were found to be approved not only for psychotic disorders and depression, respectively, but also for a variety of other psychiatric and psychological conditions.…”

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confidence: 99%

“…This discrepancy is problematic and perplexes patients and their families; moreover, it leads to a misunderstanding of the rationale for the prescription, which in turn negatively impacts adherence to pharmacotherapy. 4,5 This disease-based nomenclature is confusing not only for patients but also for medical doctors. They prescribe 'antidepressants' for anxiety disorders and 'antipsychotics' for depression.…”

mentioning

confidence: 99%

“…Indeed, we recently reported on a significant gap between the generic terminology of 'antipsychotics' and 'antidepressants' and their actual approved indications. 5 In general, more than half of 'second-generation antipsychotics' and 'newer antidepressants' were found to be approved not only for psychotic disorders and depression, respectively, but also for a variety of other psychiatric and psychological conditions. While generic names, such as 'mood stabilizers,' 'antipsychotics,' and 'antidepressants' may still be useful for communication purposes to some extent, a potential solution for this confused and confusing terminology is a proposal to move from disease-based to pharmacologydriven nomenclature.…”

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confidence: 99%

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