SummaryThis study sought to examine the prevalence of insomnia and its association with depression, anxiety, and medical comorbidities in patients after an acute coronary syndrome (ACS). Insomnia increases risk of recurrent cardiac events in ACS patients, but little is known about the prevalence and clinical correlates of insomnia in this setting. Patients (n = 102, 58.3 ± 10.6 years-old) admitted for ACS to a cardiology service at an urban academic medical center completed the Insomnia Severity Index, Epworth Sleepiness Scale, and measures of depression and anxiety. A subset (n = 20) completed ambulatory polysomnography (PSG) in their homes several weeks after discharge. Moderate or severe insomnia was reported by 37% of patients during hospitalization and was associated with 76 minutes more wake after sleep onset measured by home PSG. Although depression and insomnia were strongly associated, about 1 in 4 patients with insomnia did not report significant depressive symptoms. Sleep apnea was documented in 80% of patients on PSG, but insomnia was not associated with sleep apnea, periodic limb movements, demographic factors, or medical conditions other than liver disease. Insomnia is present in over one-third of ACS patients during hospitalization, but at-risk patients could not be readily identified by demographic or medical factors or by depression symptoms. (Int Heart J 2013; 54: 258-265) Key words: Sleep, Myocardial infarction, Angina, Depression A s many as 1 in 3 patients with acute coronary syndrome (ACS) suffer from significant psychological distress, such as depression and anxiety.1,2) Among ACS patients, depression and anxiety are associated with increased mortality, 3,4) diminished quality of life, 5) increased health care costs, 6) and reduced adherence to recommendations intended to decrease the risk of cardiac events. 7) Although insomnia is common among individuals with psychological distress, the literature on depression and anxiety as risk factors for ACS morbidity and mortality has largely ignored its potential impact in ACS patients. Instead, most of the literature on sleep in patients with heart disease has focused almost exclusively on sleep apnea due to known associations between sleep-disordered breathing (SDB) and cardiovascular morbidity. 8) Insomnia, however, is often unrelated to SDB 9,10) and is important to consider in ACS patients since poor sleep quality is associated with a 2.5-fold increased risk of recurrent cardiac events in women after an ACS.11) Insomnia has also been linked to increased morbidity, 12) mortality, 13) and health care costs 14) independent of psychological distress and in some cases, independent of SDB and periodic limb movements as well.
12)To our knowledge, no study has examined insomnia in an ACS population using a reliable, validated self-report instrument of insomnia severity that not only assesses sleep continuity and quality, but also inquires about important consequences of poor sleep, such as daytime impairment or distress.15-17) As such, this study ...