Discrepancies of video head impulse test results in patients with idiopathic sudden sensorineural hearing loss with vertigo and vestibular neuritis

Liu, Yingzhao; Leng, Yangming; Zhou, Renhong; Liu, Jingjing; Wang, Hongchang; Xia, Kaijun; Liu, Bo; Xiao, Hongjun

doi:10.3389/fnins.2023.1102512

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…The traditional sine harmonic acceleration (SHA) around the vertical axis is limited to detecting the aVOR function in the low-frequency region of the lateral semicircular canal. Although vHIT can detect all six semicircular canals, it only detects the aVOR function in the high-frequency region of each semicircular canal ( Liu et al, 2023 ; Ramaioli et al, 2023 ). Despite many studies ( Baloh et al, 1986 ; Iida et al, 2001 ; Young et al, 2001 ) have explored methods to detect the low-frequency region of the vertical semicircular canal, their clinical applicability remains limited due to the high cost, invasiveness, age restrictions, and difficulties of head position control.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional characteristics of nystagmus induced by low frequency in semicircular canals of healthy young people

Huang,

Zhang,

Deng

et al. 2024

Front. Neurosci.

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ObjectiveThe study aimed to analyze the three-dimensional characteristics of nystagmus induced by different semicircular canal combinations in healthy young people, and to determine the reference range of nystagmus slow phase velocity (SPV) and its asymmetry.Materials and methodsFifty-two healthy volunteers (26 males and 26 females, aged 17–42 years, average 23.52 ± 6.59), were recruited to perform the manual triaxial rotation testing with a 3D-Videonystagmography (3D-VNG) device (VertiGoggles (ZT-VNG-II), Shanghai ZEHNIT Medical Technology Co., Ltd., Shanghai, China) using a 0.3 Hz prompt beat and a 90° amplitude, respectively. The induced nystagmus around the Z-, X-, and Y-axes were recorded in the yaw, pitch, and roll planes. The directions and slow phase velocities of the horizontal, vertical, and torsional components of the induced nystagmus under different semicircular canal combinations (the left lateral and right lateral semicircular canal combination, bilateral anterior semicircular canals, bilateral posterior semicircular canals combination, and the anterior and posterior semicircular canals combination of each ear), as well as their asymmetry, were taken as the observation indexes to analyze the characteristics of the nystagmus vectors of different combinations.ResultsFifty-two healthy volunteers had no spontaneous nystagmus. The characteristic nystagmus was induced by the same head movement direction in all three axial rotation tests. The SPVs of the left and right nystagmus were 44.45 ± 15.75°/s and 43.79 ± 5.42°/s, respectively, when the subjects’ heads were turned left or right around the Z-axis (yaw). The SPVs of vertically upward and downward nystagmus were 31.67 ± 9.46°/s and 30.01 ± 9.20°/s, respectively, when the subjects’ heads were pitched around the X-axis (pitch). The SPVs of torsional nystagmus, with the upper poles of the eyes twisting slowly to the right and left ears (from the participant’s perspective), were 28.99 ± 9.20°/s and 28.35 ± 8.17°/s, respectively, when the subjects’ heads were turned left or right around the Y-axis (roll). There was no significant difference in the SPVs of nystagmus induced by the same rotation axis in two opposite directions (p > 0.05). The reference ranges for the slow phase velocities (SPVs) of nystagmus induced by the triaxial rotation testing were as follows: For the Z-axis (yaw), the SPVs were 13.58–75.32°/s for leftward head rotation and 13.56–74.02°/s for rightward head rotation. For the X-axis (pitch), the SPVs were 13.13–50.21°/s for upward head nystagmus and 11.98–48.04°/s for downward head nystagmus. For the Y-axis (roll), the SPVs were 10.97–47.02°/s for the left-sided head rotation and 12.34–44.35°/s for the right-sided head rotation.ConclusionThis study clarified the three-dimensional characteristics of nystagmus induced by different semicircular canal combinations in healthy young people. It also established a preliminary reference range of SPVs and SPV asymmetry of nystagmus induced by the vertical semicircular canal. It can further provide a basis for the mechanism of semicircular canal-induced nystagmus and the traceability of nystagmus in patients with otogenic vertigo. It is shown that the portable 3D-VNG eye mask can be used for the manual triaxial rotation testing to achieve the evaluation of the low-frequency angular vestibulo-ocular reflex (aVOR) function of the vertical semicircular canal, which is convenient, efficient, and practical.

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Section: Discussionmentioning

confidence: 99%

Three-dimensional characteristics of nystagmus induced by low frequency in semicircular canals of healthy young people

Huang,

Zhang,

Deng

et al. 2024

Front. Neurosci.

View full text Add to dashboard Cite

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Differences in semicircular canal function in the video head impulse test in patients in the chronic stage of sudden sensorineural hearing loss with vertigo and vestibular neuritis

Nakamichi,

Shiozaki,

Sakagami

et al. 2024

Acta Oto-Laryngologica

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Video Head Impulse Test Coherence Predicts Vertigo Recovery in Sudden Sensorineural Hearing Loss With Vertigo

Lin,

Kang

et al. 2024

Clin Exp Otorhinolaryngol

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Objectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis. We also investigated the therapeutic potential of quinidine, a known KCNK1 inhibitor, in both in vitro cell lines and a zebrafish patient-derived xenograft (PDX) model.Methods. We established primary cell cultures from head and neck cancer tissues and employed the FaDu cell line for in vitro studies, modulating KCNK1 expression through overexpression and knockdown techniques. We evaluated cell migration, invasion, and proliferation. Additionally, we developed a zebrafish PDX model to assess the impact of quinidine on tumor growth and metastasis in vivo. RNA sequencing and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to elucidate the molecular mechanisms underlying the role of KCNK1 in cancer progression.Results. Overexpression of KCNK1 in FaDu cells resulted in enhanced cell migration and invasion, whereas its knockdown diminished these processes. In the zebrafish PDX model, quinidine markedly inhibited tumor growth and metastasis, demonstrating a significant reduction in tumor volume and micrometastasis rates compared to the control groups. The molecular analyses indicated that KCNK1 plays a role in critical signaling pathways associated with tumor growth, such as the Ras and MAPK pathways.Conclusion. Our findings highlight the critical role of KCNK1 in promoting tumor growth and metastasis in head and neck cancer. The inhibitory effect of quinidine on tumor progression in the zebrafish PDX model highlights the therapeutic potential of targeting KCNK1. These results suggest that KCNK1 could serve as a valuable therapeutic target for head and neck cancer, warranting further investigation into treatments that target KCNK1.

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Discrepancies of video head impulse test results in patients with idiopathic sudden sensorineural hearing loss with vertigo and vestibular neuritis

Cited by 5 publications

References 40 publications

Three-dimensional characteristics of nystagmus induced by low frequency in semicircular canals of healthy young people

Three-dimensional characteristics of nystagmus induced by low frequency in semicircular canals of healthy young people

Differences in semicircular canal function in the video head impulse test in patients in the chronic stage of sudden sensorineural hearing loss with vertigo and vestibular neuritis

Video Head Impulse Test Coherence Predicts Vertigo Recovery in Sudden Sensorineural Hearing Loss With Vertigo

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