Discrepancy in Subfoveal Choroidal Thickness in Healthy Adults with Isometropia

Kang, Hae Min; Kim, Suk J.; Koh, Hyoung Jun; Lee, Christopher S.; Lee, Sung C.

doi:10.1016/j.ophtha.2015.05.015

Cited by 10 publications

(12 citation statements)

References 4 publications

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“…For example, Ruiz-Medrano et al 45 reported significant differences in nasal CT between left and right eye of healthy subjects. Similarly, Chen et al 46 and Kang et al 47 described discrepancies in subfoveal CT in normal populations. However, even considering these limitations, the results of the present study are noteworthy as, to the best of our knowledge, the progressive reduction of CT across all stages of NNV AMD, described in our paper, was not previously reported in a fellow-eye comparison.…”

Section: Discussionmentioning

confidence: 87%

Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study

et al. 2016

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Section: Discussionmentioning

confidence: 87%

Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study

et al. 2016

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“…Fourth, the mean age of the patients in this analysis was universally in the 40-50s, so our conclusions are valid only for this age group, although some studies have found that age does not have an effect on SFCT when the results are corrected for axial length [41]. Lastly, there are natural interocular variations of choroidal thickness [42], and other factors that can affect choroidal thickness, like smoking, axial length, central corneal thickness, and diastolic ocular perfusion pressure [41,43,44], most of which have not been accounted for in the studies included in the present analysis.…”

Section: Discussionmentioning

confidence: 99%

Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

Chen

Tzekov

et al. 2017

PLoS ONE

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PurposeTo evaluate the relationship between subfoveal choroidal thickness (SFCT) and eyes with central serous chorioretinopathy (CSC) versus fellow or control eyes.MethodsWe performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference (WMD) was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls.ResultsTwelve studies were selected for this meta-analysis, including 1108 eyes (397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls). The meta-analysis clearly demonstrated that the subfoveal choiroid of eyes with a clinical presentation of CSC was thickened compared to unaffected fellow eyes (WMD = 52.81, 95% confidence interval (CI), 39.13–66.49, P<0.00001) and was thickened compared to control eyes (WMD = 145.03, 95%CI, 121.33–168.73, P<0.00001). The mean SFCT measurement of the unaffected fellow eyes showed also significantly increased choroidal thickness compared to that of normal control eyes (WMD = 77.20, 95% CI, 44.98–109.42, P<0.00001). Similar results were obtained in a sub-analysis based on the same instrument.ConclusionIt is demonstrated that SFCT is significantly increased in eyes with clinical manifestation of CSC, and in the clinically non-manifested fellow eyes. These results support the hypothesis that CSC is a bilateral disorder with an initial unilateral clinical presentation.

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“…In healthy individuals, it has been found that SFCT on the right is thicker than on the left [12,13,15], and discrepancies in SFCT can be found between the left and right eyes [16]. Chen et al [12] described a trend for the paramacular choroid of the right eye to be thicker than that of the left eye, excluding temporal CT.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to determine which values of asymmetry should be considered as pathological signs. Retinal symmetry and optic-nerve and RNFL symmetries have been previously described [11], but studies on the choroidal distribution in healthy individuals are still limited [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography

Orduna

Sánchez‐Cano²,

Luesma³

et al. 2017

Ophthalmic Res

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Background: We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS). Methods: One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated. Normal ranges of absolute interocular differences were established as the 95th percentile. Results: The mean ± SD subfoveal CT (SFCT) and total CV values in the right and left eyes were 342.03 ± 77.38 versus 361.64 ± 76.45 µm (correlation coefficient ρ = 0.820; p < 0.001) and 0.27 ± 0.06 versus 0.28 ± 0.06 mm³ (ρ = 0.830; p < 0.001), respectively. Differences in 5 of the 9 areas of the ETDRS map were statistically significant (p < 0.05), but with a strong interocular correlation (ρ > 0.8; p < 0.001). The 95th percentile of interocular tolerance limits for CT in the 1-, 3-, and 6-mm areas were 97, 70, and 57 μm, respectively; the 95th percentile for the volume values were 0.06, 0.51, and 1.73 mm³. Conclusions: CT and CV are highly correlated between eyes, statistically significant differences between them can be found, and absolute interocular differences may reach 97 µm in SFCT, and 1.73 mm³ in total CV.

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Discrepancy in Subfoveal Choroidal Thickness in Healthy Adults with Isometropia

Cited by 10 publications

References 4 publications

Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study

Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study

Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography

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