In this paper, we first extend the hungry Lotka–Volterra lattice to a case of nonzero boundary conditions and present its corresponding exact solution expressed in terms of a block‐Hankel determinant. Then, we establish a connection between this hungry Lotka–Volterra lattice under nonzero boundary conditions and a set of biorthogonal polynomials. It turns out that the hungry Lotka–Volterra lattice under nonzero boundary conditions possesses a Lax pair expressed in terms of the biorthogonal polynomials. Moreover, we consider two special cases of the hungry Lotka–Volterra lattice. For the case , it reduces to the Lotka–Volterra lattice under nonzero boundary condition, which has been discussed in literature. We also present the result for in detail, which extends a known result to a case of nonzero boundary functions. All these results are obtained by virtue of Hirota's bilinear method and determinant techniques.