This paper tackles the problem of simulating the dynamics of human crowds in high density conditions on venues which include internal obstacles and in the interaction between two crowd streams moving in two opposite directions. The role of stress condition is taken into account as simulations aim at providing a support to crisis managers in charge of reducing the risk of incidents. The rationale of the modeling approach is that kinetic theory approach, where individual interactions, which might be nonlinearly additive, non symmetric, and non nonlocal, lead to collective behaviors to be examined towards safety problems. Author Contributions: Conceptualization, A.E. and Y.A.-T.; methodology, A.E.; formal analysis, Y.A.-T.; investigation, A.E.; writing original draft preparation, Y.A.-T.; writing review and editing, A.E. and Y.A.-T.; project administration, A.E. All authors have read and agreed to the published version of the manuscript.