Discrete microfluidics transfer across capillaries using liquid bridge stability

Lye, Jonathan Kok Keung; Ng, Tuck Wah; Ling, William Yeong Liang

doi:10.1063/1.3662191

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…This has led to efforts in incorporating microfluidics [1–3] which has resulted in arguably the smallest bioreactor possible using optical tweezers [4]. In the realm of microfluidics, there is a trend towards the use of discrete volume systems that offer flexible and scalable system architectures as well as high fault tolerance capabilities [5–7]. Moreover, because sample volumes can be controlled independently, such systems have greater ability for reconfiguration whereby groups of unit parts in an array can be altered to change their functionality.…”

Section: Introductionmentioning

confidence: 99%

Optical stirring in a droplet cell bioreactor

Muradoglu

Lau

et al. 2012

Biomed. Opt. Express

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In the context of a bioreactor, cells are sensitive to cues from other cells and mechanical stimuli from movement. The ability to provide the latter in a discrete fluidic system presents a significant challenge. From a prior finding that the location of the focus of a laser below particles relative to the beam axis producing a pushing effect in a predominant lateral sense, we advance an approach here that generates a gentle and tunable stirring effect. Computer simulation studies show that we are able to characterize this effect from the parameters that govern the optical forces and the movement of the particles. Experimental results with polystyrene microbeads and red blood cells confirm the notions from the simulations.

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Section: Introductionmentioning

confidence: 99%

Optical stirring in a droplet cell bioreactor

Muradoglu

Lau

et al. 2012

Biomed. Opt. Express

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“…( 26), differentiating in the x-direction, and then substituting the results into Eqs. ( 16) and (17), respectively, yield the complete evolution equations for the precursor film model,…”

Section: B Temperature Fieldmentioning

confidence: 99%

“…[8][9][10][11] Surface roughness or local chemical heterogeneity often results in wettability differences on a solid wall, and these heterogeneities occurring on the microscale lead to the deformation 12 or stick-slip 13 of contact line motion. These phenomena have been widely used in microfluidic devices to drive droplets and bubbles [14][15][16][17][18] and have important applications in inkjet printing, coatings, microelectronics, and medical diagnostics. [19][20][21][22][23] The lubrication approximation 24,25 is an important method for modeling moving contact line problems.…”

Section: Introductionmentioning

confidence: 99%

Thermocapillary migration of a droplet on a substrate with wettability difference: A comparison between slip and precursor film models in three dimensions

Li,

Xie,

Xiong

et al. 2024

Journal of Applied Physics

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Moving contact line dynamics calculations include two models: precursor film models and slip models. The lubrication approximation method is used to establish a three-dimensional mathematical model to analyze the droplet thermocapillary migration behavior on a non-uniformly heated solid substrate with a wettability track. The contact line dynamics in the slip model and the disjoining pressure effect in the precursor model are proposed to regulate the substrate wettability. Both models are numerically implemented to investigate droplet spreading for three cases: free spreading on an isothermal substrate, thermocapillary migration on a uniform wettability substrate, and thermocapillary migration on a wettability-confined track. For the case of free spreading on an isothermal substrate, the three-dimensional results of the slip and precursor contact line models are essentially consistent with two-dimensional slip model results. For the case of thermocapillary migration on a uniform wettability substrate, the results of the two models essentially agree with the experimental results. Decreasing the thermal gradient reduces the discrepancies between the two models that result from the coordinate transformation method used in the slip model, which reduces the contact angles measured in the y-direction and enlarges the advancing contact angle in the migration direction. For the case of thermocapillary migration on a wettability-confined track, the slip model gradually shows a “dynamic-pinning” behavior with increasing equilibrium contact angle in the hydrophobic region. By contrast, the precursor film model maintains a stationary pinning behavior but separates a residual liquid outside the track. The precursor film model is preferred over the slip model in lubrication approximations for three-dimensional fluids when calculating complex moving contact dynamics caused by wettability differences. However, the precursor film model must be further optimized to prevent numerical instability.

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“…The basic technique for printing is to control the liquid volume transferred from one surface to another. In microfluidics, such as those used in chemical engineering and biological sciences, there is a general need to accurately manipulate a droplet, and liquid bridges are usually adopted as a tool to merge, transport, or reshape droplets. − In these applications, designing a controllable liquid transfer between two surfaces is a basic requirement for various industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Rupture of Liquid Bridges on Porous Tips: Competing Mechanisms of Spontaneous Imbibition and Stretching

Suo

Gan

2020

Langmuir

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Liquid bridges are commonly encountered in nature and the liquid transfer induced by their rupture are widely used in various industrial applications. In this work, with the focus on the porous tip, we studied the impacts of capillary effects on the liquid transfer induced by the rupture through numerical simulations. To depict the capillary effects of a porous tip, a time scale ratio, 𝑅 𝑇 , is proposed to compare the competing mechanisms of spontaneous imbibitiona and external drag. In terms of 𝑅 𝑇 , we then develop a theoretical model for estimating the liquid retention ratio considering the geometry, porosity and wettability of tips. The mecahnism presented in this work provides a possible approach to control the liquid transfer with better accuracy in microfluidics or microfabrications.

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Discrete microfluidics transfer across capillaries using liquid bridge stability

Cited by 10 publications

References 27 publications

Optical stirring in a droplet cell bioreactor

Optical stirring in a droplet cell bioreactor

Thermocapillary migration of a droplet on a substrate with wettability difference: A comparison between slip and precursor film models in three dimensions

Rupture of Liquid Bridges on Porous Tips: Competing Mechanisms of Spontaneous Imbibition and Stretching

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