“…The logistic regression/COX model showed that FVTC, whether as a continuous or a categorical variable, was positively correlated with the occurrence of AKI, ICU mortality, and in-hospital mortality when unadjusted. The results of VIFs prior to multivariate analysis were listed in Supplementary Table S1 , with VIFs between 1 and 5 for each variable, illustrating the absence of multicollinearity problems ( 27 ). After adjusted by age, weight, gender, SOFA score, type of patient's first admission to ICU, ventilator use, vasopressor use, comorbidities, source of infection, infectious pathogen, co-infection with Gram-negative bacilli, duration of vancomycin use, vital signs, and the laboratory test result, FVTC was still a risk factor with the occurrence of AKI (OR: 1.02; 95% CI:1.01–1.04), ICU mortality (HR:1.02; 95% CI:1.01–1.03), and in-hospital mortality (HR:1.02; 95% CI:1.01–1.03), which means that for every unit increase in FVTC, the risk of AKI, ICU and in-hospital mortality increases by 1.02 times.…”