Discrimination among Rhinovirus Serotypes for a Variant ICAM-1 Receptor Molecule

Xiao, Chuan; Tuthill, Tobias J.; Kelly, Carol M. Bator; Challinor, Lisa; Chipman, Paul R.; Killington, R. A.; Rowlands, David J.; Craig, Alister G.; Rossmann, Michael G.

doi:10.1128/jvi.78.18.10034-10044.2004

Cited by 20 publications

(22 citation statements)

References 60 publications

(81 reference statements)

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“…Studies on human rhinovirus (HRV) using two different HRV serotypes have shown varying adhesion phenotypes to ICAM-1 Reference and ICAM-1 Kilifi , and their association with varying clinical outcome [88]. A similar situation may occur in P. falciparum variants from the field as shown in this study and in laboratory lines [63] that exhibit differential adhesion abilities to all three ICAM-1 proteins.…”

Section: Discussionsupporting

confidence: 63%

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

et al. 2011

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Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases.

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Section: Discussionsupporting

confidence: 63%

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

et al. 2011

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“…Although many different cellular factors have been identified as entry receptors, the visualization of picornavirus-receptor interactions at atomic or near-atomic resolution is still relatively rare, due in some cases to the inherent flexibility of the receptor binding portions. A number of enterovirus receptor complexes have been determined, including: PV with CD155 (9-11), major group HRV and CVA21 with intercellular adhesion molecule 1 (ICAM-1), minor group HRV with very-low-density lipoprotein receptor (VLDLR) (12)(13)(14)(15), and CVB3 with coxsackievirusadenovirus receptor (CAR) and decay-accelerating factor (DAF) Significance Seneca Valley virus (SVV) selectively infects and lyses neuroendocrine cancer cells, including small-cell lung cancer (SCLC) and pediatric neuroendocrine solid tumors, which are a major cause of morbidity and mortality. It is under development in clinical trials as an oncolytic agent against these tumors.…”

Section: Seneca Valley Virus (Svv)mentioning

confidence: 99%

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1

Cao

Zhang

Liu

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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wrote the paper.The authors declare no conflict of interest. This article is a PNAS Direct Submission.Published under the PNAS license.Data deposition: The cryo-EM density maps and structures have been deposited in the Protein Data Bank, www.pdb.org, and the Electron Microscopy Data Bank (EMD) [accession nos.: mature particles in pH 8, 6ADT and EMD-9613; mature particles in pH 6, 6ADS and EMD-9612; SVV(full)-ANTXR1 in pH 8, 6ADR and EMD-9611; SVV(full)-ANTXR1 in pH 6, 6ADM and EMD-9608; and SVV(spent)-ANTXR1, 6ADL and EMD-9607].

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“…Assignment of an RV to a given species is based on sequences of the VP4/VP2 or VP1 proteins (11). In most RVs, binding and fusion of the viral particle are mediated by attachment to ICAM-1 (12), which binds to a pocket groove of the VP-1 protein (13). Other subtypes of RVs bind to LDL receptor family receptors.…”

mentioning

confidence: 99%

Understanding the Association of Human Rhinovirus with Asthma

Stone

Miller

2016

Clin Vaccine Immunol

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Human rhinoviruses are ubiquitous seasonal pathogens. They have known associations with first onset of wheezing illnesses in children and with asthma exacerbations in patients of all ages. It is not yet certain whether human rhinoviruses play a direct role in the pathogenesis of asthma by activating deleterious inflammatory responses or if they only serve as a catalyst to accelerate the disease in genetically predisposed individuals. There have been previously demonstrated reductions in the development of the asthmatic phenotype with passive immunization against respiratory syncytial virus; however, in the case of rhinovirus, there are barriers to effective vaccine development, such as the lack of a common antigenic target due to alterations of surface markers among subtypes. It remains to be determined whether certain subtypes of human rhinovirus are more asthmagenic and therefore worthy of greater attention as vaccine candidates, but several studies have suggested that RV-C and certain RV-A strains may be more strongly linked with asthma.

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Discrimination among Rhinovirus Serotypes for a Variant ICAM-1 Receptor Molecule

Abstract: Kilifi contain one less salt bridge than between the viruses and ICAM-1. As HRV16 has fewer overall interactions with ICAM-1 than HRV14, the absence of this charge interaction has a greater impact on the binding of ICAM-1 Kilifi to HRV16 than to HRV14.

Cited by 20 publications

References 60 publications

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1

Understanding the Association of Human Rhinovirus with Asthma

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