Discrimination Between Benign and Malignant Adnexal Masses by Specialist Ultrasound Examination Versus Serum CA-125

Calster, Ben Van; Timmerman, Dirk; Bourne, Tom; Testa, Antonia Carla; Holsbeke, C. Van; Domali, E.; Jurkovic, D.; Neven, Patrick; Huffel, Sabine Van; Valentin, Lil

doi:10.1093/jnci/djm199

Cited by 194 publications

(149 citation statements)

References 37 publications

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“…Prospective validation of these simple ultrasound rules in a sample of women with adnexal masses yielded a sensitivity of 95%, a specificity of 91%, positive likelihood ratio of 10.37 and negative likelihood ratio of 0.06 56 . This study has also demonstrated that although pattern recognition of ultrasound findings by an experienced examiner can not only reproducibly discriminate between benign and malignant adnexal masses, it is superior to serum CA125 57 . The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is a randomized control trial evaluating the effect of screening on mortality 58 .…”

Section: How Effective Is Ultrasound In Detecting Early Stage Ovarianmentioning

confidence: 68%

Preventive Strategies in Epithelial Ovarian Cancer

Mantia‐Smaldone¹,

Scholler²

2012

Ovarian Cancer - Clinical and Therapeutic Perspectives

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Section: How Effective Is Ultrasound In Detecting Early Stage Ovarianmentioning

confidence: 68%

Preventive Strategies in Epithelial Ovarian Cancer

Mantia‐Smaldone¹,

Scholler²

2012

Ovarian Cancer - Clinical and Therapeutic Perspectives

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“…Pattern recognition by ultrasound examination is another modality for discrimination between benign and malignant adnexal masses are considered superior to serum CA 125 estimation. 6 But this too has limitations as in our case the broad ligament leiomyoma mimicked ovarian cyst sonographically. The degenerative changes in the leiomyoma can lead to this confusion.…”

mentioning

confidence: 62%

Leiomyoma of Broad Ligament Mimicking Ovarian Malignancy– Report of a Unique Case

Mallick

Saha

Chakrabarti

et al. 2015

Kathmandu Univ. Med. J.

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Tumors of the broad ligament are uncommon. Leiomyoma, which is the commonest female genital neoplasm, is also the most common solid tumor of the broad ligament. Leiomyomas affect 30% of all women of reproductive age but the incidence of broad-ligament leiomyoma is <1%. These benign tumors are usually asymptomatic. A case is being described where a 52 year old presented with gradual abdominal swelling which was clinically and radiologically diagnosed as ovarian malignancy. On abdominal and bimanual palpation a soft cystic mass was noted in the right pelvic region. CA 125 was mildly raised. CEA, CA 19.9 levels were within normal limit. The radiological diagnosis was ovarian cyst with possibility of malignant changes. Staging laparotomy and histopathological examination of the resected specimen revealed a right sided broad ligament leiomyoma with cystic changes. The degenerative changes in the leiomyoma lead to the clinical and radiological diagnostic confusion. Thus, though uncommon, broad ligament leiomyoma should be considered during evaluation of adnexal masses for optimal patient management. The above description of leiomyoma in the broad ligament is a highly unique case and thus deserves appropriate attention. KEY WORDSBroad ligament mass, cystic changes, clinical and radiological diagnosis, leiomyoma.

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“…The study of Benvancalster et al showed that ultrasound examiners assigned a correct specific diagnosis to at least 80% of endometriomas and 84% of dermoid cysts [21].…”

Section: Resultsmentioning

confidence: 99%

“…Clinicians remain unable to diagnose simultaneous presence of two distinct pathologies in a single ovary. Moreover, it was reported that the level of serum CA-125 is often elevated in women with endometriomas and in cystic teratomas [21].…”

Section: Discussionmentioning

confidence: 99%