Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios

Yang, Qiuping; Song, Jie; Deng, Zhirong; Shi, Congcong; Li, Sitao; Zhuang, Guiying; Hao, Hu; Cai, Yao

doi:10.1007/s00431-023-05171-1

Cited by 1 publication

(1 citation statement)

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“…It is not only used for disease diagnosis and prognosis assessments, but also serves as an important means of exploring new therapeutic approaches for diseases (6). Among the plethora of metabolomics research methodologies, tandem mass spectrometry (MS/MS) is a fundamental technique that has been extensively utilized in the investigation of newborns and the treatment of inherited metabolic diseases (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics profiling reveals low blood tyrosine levels as a metabolic feature of newborns from systemic lupus erythematosus pregnancies

Cai,

Deng,

Yang

et al. 2024

Front. Immunol.

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IntroductionPregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear.MethodsIn this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants.ResultsWe found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE.DiscussionBy constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE.

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