Discrimination of various contributions to the absorbed dose in BNCT: Fricke-gel imaging and intercomparison with other experimental results

Gambarini, G.; Agosteo, S.; Marchesi, P.; Nava, E.; Palazzi, P.; Pecci, A.; Rosi, G.; Tinti, R.

doi:10.1016/s0969-8043(00)00220-7

Cited by 31 publications

(24 citation statements)

References 8 publications

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“…Nevertheless, this potential drawback is suitably overcome by an improved 2D analyzing technique based on almost monochromatic sample transmission imaging 3 , 11 , 18 , 22 , 24 , 28 . As expected, the presence of linearity in dose response is reduced to specific dose ranges, observing initial dose interval without appreciable response, as well as saturation effects at higher dose levels.…”

Section: Discussionmentioning

confidence: 99%

“…Determination of stable free radicals produced during irradiation can be achieved using different analytical methods, like magnetic resonance or an inexpensive alternative readout based on spectrophotometry, proposed by Gupta et al 15 , 16 The FXG dosimetry by thin layers optically analyzed, originally developed by Prof. Gambarini, 17 , 18 has been demonstrated to be a suitable and reliable tool for wide applications, including standard radiation therapy modalities, like intensity‐modulated radiotherapy, (19) measurements of dose profiles and multiple fields irradiations, 11 , 20 , 21 and high‐dose‐rate brachytherapy, (22) among other conventional and nonconventional procedures. The latter include mainly Boron neutron capture therapy (BNCT), for which this technique proved to be even capable of assessing the different dose contributions, then separating therapeutic from other components 23 , 24 , 25 , 26 , 27 , 28 , 29 …”

Section: Introductionmentioning

confidence: 99%

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Fricke gel dosimeter with improved sensitivity for low‐dose‐level measurements

Valente

Molina

Silva

et al. 2016

J Applied Clin Med Phys

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Fricke solution has a wide range of applications as radiation detector and dosimetry. It is particularly appreciated in terms of relevant comparative advantages, like tissue‐equivalence when prepared in aqueous media like gel matrix, continuous mapping capability, independence of dose rate and incident direction, as well as linear dose response. This work presents the development and characterization of an improved Fricke gel system, based on modified chemical compositions, making possible its application in clinical radiology due to its improved sensitivity. Properties of standard Fricke gel dosimeter for high‐dose levels are used as a starting point, and suitable chemical modifications are introduced and carefully investigated in order to attain high resolution for low‐dose ranges, like those corresponding to radiology interventions. The developed Fricke gel radiation dosimeter system achieves the expected typical dose‐dependency, showing linear response in the dose range from 20 up to 4000 mGy. Systematic investigations including several chemical compositions are carried out in order to obtain an adequate dosimeter response for low‐dose levels. A suitable composition from among those studied is selected as a good candidate for low‐dose‐level radiation dosimetry consisting of a modified Fricke solution fixed to a gel matrix containing benzoic acid along with sulfuric acid, ferrous sulfate, Xylenol orange, and tridistilled water. Dosimeter samples are prepared in standard vials for in‐phantom irradiation and further characterization by spectrophotometry measuring visible light transmission and absorbance before and after irradiation. Samples are irradiated using typical X‐ray tubes for radiology and calibrated Farmer‐type ionization chamber is used as reference to measure dose rates inside phantoms at vial locations. Once sensitive material composition is optimized, dose‐response curves show significant improvement regarding overall sensitivity for low dose levels. The aim of this work consists of implementing the optimized gel dosimeter to perform direct measurements of absorbed dose in samples irradiated during microcomputed tomography scanning in order to preliminary assess dose levels for further scanning of small animals for further applications in veterinary and paleontology. As a first attempt, dose distributions were measured in water‐equivalent phantoms having dimensions comparable to small animals, 100 to 1000 cm3, approximately. According to the obtained results, it is found that the proposed method shows satisfactory reliability and adequate performance for a promising gel dosimetry system.PACS number(s): 87.53.Bn, 87.57.uq, 87.59.‐e

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fricke gel dosimeter with improved sensitivity for low‐dose‐level measurements

Valente

Molina

Silva

et al. 2016

J Applied Clin Med Phys

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“…Many existing dosimetric techniques have been improved, and many new dosimetric systems have been discovered and developed. These techniques include thermoluminescence dosimetry (6), scintillation dosimetry through lithium gadolinium borate (7) and lithium acetate (8), chemical dosimetry with chlorobenzene-ethanol-trimethylpentane (9), and gel dosimetry (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Gadolinium on the ESR Response of Alanine and Ammonium Tartrate Exposed to Thermal Neutrons

et al. 2008

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“…Current dosimeters include activation foils and wires, paired ionization chambers, and thermoluminescent dosimeters, all of which make mapping a 3D dose distribution laborious. ( 13 – 18 ) The properties of dosimetry gels make these substances suitable for determining 3D dose distributions in large and complex geometries. This approach is advantageous for BNCT: first, for beam dosimetry (experimentally verifying dose distribution in standard phantoms in three dimensions), and second, for verification of treatment planning in complex geometries such as the head and neck.…”

Section: Introductionmentioning

confidence: 99%

“…( 7 , 9 , 12 , 18 ) That research group reported using Fricke gel dosimeters of varying composition to separate the dose components of the beam (18) . The drawback of Fricke gel dosimeters is deterioration of dose distribution because of diffusion of ferric ions (19) .…”

Section: Introductionmentioning

confidence: 99%

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Uusi-Simola

Heikkinen

Kotiluoto

et al. 2007

J Applied Clin Med Phys

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Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry.PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff

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Discrimination of various contributions to the absorbed dose in BNCT: Fricke-gel imaging and intercomparison with other experimental results

Cited by 31 publications

References 8 publications

Fricke gel dosimeter with improved sensitivity for low‐dose‐level measurements

Fricke gel dosimeter with improved sensitivity for low‐dose‐level measurements

The Effect of Gadolinium on the ESR Response of Alanine and Ammonium Tartrate Exposed to Thermal Neutrons

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

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