This book draws on more than 25 years of experience developing and evaluating anti-stigma programs to reduce negative and unfair treatment experienced by people with a mental or substance use disorder. It builds on a previous edition, Paradigms Lost: Fighting Stigma and the Lessons Learned, that identified new approaches to stigma reduction. This volume examines the newest approaches to stigma reduction with respect to structural stigma, public stigma, and internalized stigma. The goals of anti-stigma work must be to eliminate the social inequities that people with mental and substance use disorders and their families face to promote their full and effective social participation. Awareness raising and mental health literacy are important, but they do little to change the accumulated practices of social groups and social structures that systematically disadvantage those with mental and substance use problems. The book is written with one eye to the past (what we have done well) and one to the future (what we must still do). It goes into depth in targeted areas such as healthcare, workplaces, schools, and the media. We expect that this edition will be a useful sequel to Paradigms Lost, chronicling what we have learned as a global community regarding stigma related to mental illness and substance use and stigma-reduction approaches.