Discriminative conditioning-related slow potential and single-unit responses in the frontal cortex of urethane-anesthetized rats

Corbus, Mary Jo; Pirch, James H.

doi:10.1016/0006-8993(86)90201-5

Cited by 12 publications

(6 citation statements)

References 18 publications

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“…Similar to the human CNV, shifts in rat SP reflects learning of the association between the CS+ and a reward, and the SP also shows extinction upon removal of the reward. These SP characteristics are independent of the CS modality (tone, light or subthreshold brain stimulation) and type of reinforcer (food, rewarding brain stimulations, footshock) (Rucker et al, 1986; Pirch, 1993), and clearly involve dopaminergic transmission (Pirch et al, 1981; Pirch, Napier and Corbus, 1981; Pirch and Corbus, 1983). The SPs correlate with event-related changes in single neuron firing in both the frontal cortex (Pirch and Peterson, 1981; Pirch et al, 1985) as well as in the VP (Rigdon and Pirch, 1986; note: only a caudal portion of VP was tested, which was termed the substantia innominata in this report).…”

Section: 0 Vp Influences On Behaviormentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

312

362

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The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally-relevant stimuli and coherent adaptive behaviors.

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Section: 0 Vp Influences On Behaviormentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

312

362

View full text Add to dashboard Cite

show abstract

“…The drive to obtain this artificial reinforcer can cause animals to press a lever inducing MFB stimulation (also referred to as intracranial self‐stimulation) to the extent of disregarding primal physiological needs of natural reinforcers such as food or water (Olds & Milner, 1954). MFB stimulation is effective in producing conditioning even when the subjects are anesthetized (Pirch, 1993; Rucker, Corbus, & Pirch, 1986), immobilized (Shinkman, Bruce, & Pfingst, 1974) or when delivered during natural sleep (de Lavilleon, Lacroix, Rondi‐Reig, & Benchenane, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bilateral responses of rat ventral striatum tonically active neurons to unilateral medial forebrain bundle stimulation

Markovich‐Molochnikov

Cohen

2020

Eur J of Neuroscience

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Unilateral medial forebrain bundle (MFB) stimulation is an extremely effective promoter of reinforcement learning irrespective of the conditioned cue's laterality. The effectiveness of unilateral MFB stimulation, which activates the mesolimbic pathway connecting the ventral tegmental area to the ventral striatum (vStr), is surprising considering that these fibers rarely cross to the contralateral hemisphere. Specifically, this type of biased fiber distribution entails the activation of brain structures that are primarily ipsilateral to the stimulated MFB, along with weak to negligible activation of the contralateral structures, thus impeding the formation of a cue-outcome association. To better understand the spread of activation of MFB stimulation across hemispheres, we studied whether unilateral MFB stimulation primarily activates the ipsilateral vStr or the vStr of both hemispheres. We simultaneously recorded neuronal activity in the vStr of both hemispheres in response to several sets of unilateral MFB stimulation in anesthetized and freely moving rats. Unilateral MFB stimulation evoked strong stimulus-dependent activation of vStr tonically active neurons (TANs), presumably the cholinergic interneurons, in both hemispheres. However, the TANs' activation patterns and responsiveness depended on whether the stimulus was delivered ipsilaterally or contralaterally to the recorded neuron. These findings indicate that unilateral MFB stimulation effectively activates the vStr in both hemispheres in a stimulus-dependent manner which may serve as neuronal substrate for the formation of cue-outcome associations during reinforcement learning.

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“…Previous reports have demonstrated that CNV-like and P 300 -like waveforms could be obtained by 'passive' procedure in rats (Ebenezer, 1986;Nakamura et al, 1993;Rucker et al, 1986;Takeuchi et al, 1999). The 'passive' procedure of ERPs is especially suitable for the empirical study in anesthetized rats because of the convenient application and the exclusion of perturbation of autonomic activities of animals (Ebenezer, 1986;O'Brien, 1982;Rucker et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…The 'passive' procedure of ERPs is especially suitable for the empirical study in anesthetized rats because of the convenient application and the exclusion of perturbation of autonomic activities of animals (Ebenezer, 1986;O'Brien, 1982;Rucker et al, 1986). Although the interference of anesthetized state might decrease the amplitudes of ERPs, some studies have found that the ERPs latencies and scalp distribution were similar with those in human (Ebenezer, 1986;O'Brien, 1982).…”

Section: Introductionmentioning

confidence: 99%

Findings of P300-like and CNV-like potentials in rat model of depression following repeatedly forced swim stress

Guo

Zheng

Han

et al. 2009

International Journal of Psychophysiology

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Discriminative conditioning-related slow potential and single-unit responses in the frontal cortex of urethane-anesthetized rats

Cited by 12 publications

References 18 publications

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Bilateral responses of rat ventral striatum tonically active neurons to unilateral medial forebrain bundle stimulation

Findings of P300-like and CNV-like potentials in rat model of depression following repeatedly forced swim stress

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