Discriminatory power of MALDI-TOF MS protein profiling analysis of pork meat and meat products

Šedo, Ondrej; Roblíčková, Alena; Ježek, František; Gintar, Petr; Kameník, Josef; Zdráhal, Zbyněk

doi:10.1016/j.foodchem.2024.139155

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…MALDI-TOF-MS is still used today, e.g. for the analysis of immunoprecipitated proteins [17], for protein profiling of food products [18], causative agents of diseases such as bacteria [19], fungi [20], viruses [21,22], or for in-situ-proteomics in embedded tissues [23].…”

Section: From Protein Sequencing To Proteomicsmentioning

confidence: 99%

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools – Chances and Limitations. A Critical Review

Müller,

Boubaker,

Müller

et al. 2024

Preprint

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Identification of drug targets and biochemical investigations on mechanisms of action is a are major issues in modern drug development. The present article reviews the classical “one drug” – “one target” paradigm. Novel methods for target deconvolution and for investigation of resistant strains based on protein mass spectrometry have shown that multiple gene products and adapta-tion mechanisms are involved in responses of pathogens to xenobiotics. This review is focused on protozoan pathogens. The conclusions can, however, be extended to chemotherapies against other pathogens or cancer. For this review we have searched Pubmed (pubmed.ncbi.nlm.nih.gov) and Web of Science (webofscience.com) using the key words listed below (status May 2024)

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Section: From Protein Sequencing To Proteomicsmentioning

confidence: 99%

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools – Chances and Limitations. A Critical Review

Müller,

Boubaker,

Müller

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The resulting ions are then separated according to their time of flight (TOF), lighter ions being faster than heavier ions, and their m/z is determined based on time used to arrive at the detector [16]. MALDI-TOF-MS is still used today, e.g., for the analysis of immunoprecipitated proteins [17], for protein profiling of food products [18], to identify causative agents of diseases such as bacteria [19], fungi [20], viruses [21,22], or for in situ proteomics in embedded tissues [23].…”

Section: From Protein Sequencing To Proteomicsmentioning

confidence: 99%

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review

Müller,

Boubaker,

Müller

et al. 2024

IJMS

View full text Add to dashboard Cite

Identification of drug targets and biochemical investigations on mechanisms of action are major issues in modern drug development. The present article is a critical review of the classical “one drug”—“one target” paradigm. In fact, novel methods for target deconvolution and for investigation of resistant strains based on protein mass spectrometry have shown that multiple gene products and adaptation mechanisms are involved in the responses of pathogens to xenobiotics rather than one single gene or gene product. Resistance to drugs may be linked to differential expression of other proteins than those interacting with the drug in protein binding studies and result in complex cell physiological adaptation. Consequently, the unraveling of mechanisms of action needs approaches beyond proteomics. This review is focused on protozoan pathogens. The conclusions can, however, be extended to chemotherapies against other pathogens or cancer.

show abstract

Discriminatory power of MALDI-TOF MS protein profiling analysis of pork meat and meat products

Cited by 2 publications

References 41 publications

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools – Chances and Limitations. A Critical Review

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools – Chances and Limitations. A Critical Review

Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review

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