Discriminatory power of MRI for differentiation of adrenal non-adenomas vs adenomas evaluated by means of ROC analysis: Can biopsy be obviated?

Abstract

The purpose of our study was to evaluate the discriminatory power of MRI in high-field magnet (1.5 T) for differentiation of adrenal non-adenomas vs adenomas assessing the following parameters separately and in combination: mean diameter of adrenal mass; previously described and new ratios as well as index calculated from signal intensity (SI) on SE T2-weighted images, chemical shift imaging (CSI), and Gd-DTPA-enhanced dynamic studies. One hundred eight adrenal masses (36 non-hyperfunctioning adenomas, 27 pheochromocytomas, 23 aldosterone-secreting adenomas, 20 malignant masses and 2 cortisol-secreting adenomas) in 95 patients were evaluated with SE sequences, CSI and Gd-DTPA dynamic studies. Indices and ratios of SI for all examined MRI methods were calculated and examined retrospectively for significance of differences between the groups with calculation of sensitivity and specificity. Receiver operating characteristics (ROC) analysis of calculated parameters in combination was performed. The multifactorial analysis of all four parameters, including size of the tumor, T2(liver) index, CSI ratio reflecting lipid content in the tumor and Wo(max/last) ratio reflecting maximal washout of contrast agent from the tumor had 100 % sensitivity and 100 % specificity in characterization of adrenal non-adenoma. The best performance of combination of mean tumor diameter with single MRI SI parameter was achieved in combination with T2(liver) index for all adrenal masses (area under ROC 0.987) and CSI ratio for non-hyperfunctioning adrenal masses (area under ROC 0.991). Magnetic resonance imaging enables sensitive and specific diagnosis of adrenal non-adenoma.

Adrenal phaeochromocytoma: correlation of MRI appearances with histology and function

“…5). Using the SI index (SII) signal loss greater than 1-16.5% have been reported [27,30,32]. A 100% accuracy for differentiating adenomas and non-adenomas has been reported in separate studies by Tsushima et al and [27] Fujiyoshi et al [30] using SII threshold values of >5% and >16.5%, respectively.…”

Computertomographie und Magnetresonanztomographie in der Differentialdiagnose von Nebennierenraumforderungen

“…Ichikawa et al [39] berichten über eine Sensitivität von 92% und eine Spezifität von 95% bei Anwendung dieses Kriteriums. Die CSI scheint bisher von allen untersuchten MRT-Techniken am genauesten zu sein (Abbildung 1) [37,[40][41][42].…”

Adrenal Imaging Methods: Comparison of Mean CT Attenuation, CT Histogram Analysis and Chemical Shift Magnetic Resonance Imaging for Adrenal Mass Characterization and Review of the Literature

“…Magnetic resonance imaging (MRI) using in-phase and opposed-phase images, known as chemical-shift MRI, has been proposed as an effective alternative to CT for characterization of adrenal masses. (6,7). Quantitative analysis of the signal intensity of adrenal lesions compared with that of the liver, fat, muscle and image background was subsequently shown to improve characterization of adrenal masses compared with qualitative analysis of signal intensity variations.…”