Discussion Addendum for: Nickel‐Catalyzed Cross‐Coupling of Aryl Halides with Alkyl Halides: Ethyl 4‐(4‐(4‐Methylphenylsulfonamido)‐Phenyl)butanoate

Abstract

This chapter describes the procedure for nickel‐catalyzed cross‐coupling of aryl halides with alkyl halides: ethyl 4‐(4‐(4‐methylphenylsulfonamido)‐phenyl)butanoate. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. While alkyl halides are far more abundant than alkyl organometallic reagents, the largest commercially available pools of aliphatic electrophile diversity are alcohols, amines, and alkanoic acids.