Although authors often create literary texts in order to comment on issues of personhood and human relationships, reading and writing about literary texts in schools is often focused on close analysis of literary elements or exploration of one’s own experience with the text. Thus, students’ written arguments about literature typically do little work in the world toward understanding the human condition. In response, we argue for a theoretical and instructional framework of reading and writing about literature called Dialogic Literary Argumentation. Dialogic literary argumentation asks students and teachers to engage in reading, dialogue, and argumentative writing about how they and others make meaning out of literary texts, what the meaning says about what it means to be human together, and how we might act in and on the worlds in which we live. In this article, we explicate the various elements of this theoretical framework that situates the student’s literary argument within their own cognitive processes, social interactions in classroom events, and broader sociocultural contexts. Students’ composed arguments draw on multiple texts (the literary text, others in and beyond the classroom, their own experiences, the literary discipline, and the world), which are mediated by various classroom dialogues, scaffolds, and supports.