Discussion of the protein characterization techniques used in the identification of membrane protein targets corresponding to tumor cell aptamers

Guo, Zhukang; Liu, Yuan; He, Nongyue; Deng, Yan; Jin, Lian

doi:10.1016/j.cclet.2020.11.061

Cited by 45 publications

(15 citation statements)

References 131 publications

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“…The intracellular-controlled release of DOX via a pH-sensitive hydrazone killed tumor cells effectively. Owing to the AS1411 aptamer, the nanoplatform had excellent specificity for tumor cells, whose membrane nucleolin were overexpressed [ 116 , 117 ]. This nanoplatform has the potential for bioimaging and the treatment of tumors with high specificity and efficiency.…”

Section: Aptamer-bound Nanomaterials Used In Different Cancer Therapiesmentioning

confidence: 99%

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

et al. 2021

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Cancer is still a major disease that threatens human life. Although traditional cancer treatment methods are widely used, they still have many disadvantages. Aptamers, owing to their small size, low toxicity, good specificity, and excellent biocompatibility, have been widely applied in biomedical areas. Therefore, the combination of nanomaterials with aptamers offers a new method for cancer treatment. First, we briefly introduce the situation of cancer treatment and aptamers. Then, we discuss the application of aptamers in breast cancer treatment, lung cancer treatment, and other cancer treatment methods. Finally, perspectives on challenges and future applications of aptamers in cancer therapy are discussed.

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Section: Aptamer-bound Nanomaterials Used In Different Cancer Therapiesmentioning

confidence: 99%

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

et al. 2021

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“…Aptamers have high affinity and specificity, which can realize the sensitive detection of two tumor markers. − For instance, Liu et al used an aptamer-based histochemistry assay to specifically diagnose and discriminate diversiform cancer markers. The introduction of aptamer made the detection efficient.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

et al. 2022

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Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05− 10000 and 1−10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

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“…Due to the ease with which stimuli-sensitive director configuration transitions may be implemented in flat geometries [ 19 , 20 ], in spherical geometries, i.e., droplets [ 21 , 22 , 23 ], and in shells [ 24 , 25 ], using LCs to identify chemical and biological species has become very common [ 26 ]. They can achieve the same or even better results than other sensing technologies [ 27 , 28 , 29 ]. Depending on how the orientation at the LC surface affects the structure throughout the droplet, the geometric confinements of the LC droplets can take on various forms.…”

Section: Introductionmentioning

confidence: 99%

Liquid Crystal Droplet-Based Biosensors: Promising for Point-of-Care Testing

Xie

et al. 2022

Biosensors

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The development of biosensing platforms has been impressively accelerated by advancements in liquid crystal (LC) technology. High response rate, easy operation, and good stability of the LC droplet-based biosensors are all benefits of the long-range order of LC molecules. Bioprobes emerged when LC droplets were combined with biotechnology, and these bioprobes are used extensively for disease diagnosis, food safety, and environmental monitoring. The LC droplet biosensors have high sensitivity and excellent selectivity, making them an attractive tool for the label-free, economical, and real-time detection of different targets. Portable devices work well as the accessory kits for LC droplet-based biosensors to make them easier to use by anyone for on-site monitoring of targets. Herein, we offer a review of the latest developments in the design of LC droplet-based biosensors for qualitative target monitoring and quantitative target analysis.

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Discussion of the protein characterization techniques used in the identification of membrane protein targets corresponding to tumor cell aptamers

Cited by 45 publications

References 131 publications

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

Liquid Crystal Droplet-Based Biosensors: Promising for Point-of-Care Testing

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