Discussion

Rg, Pendleton; Rasheed, Aseel; Roychowdhury, Rupanjali; Hillman, Ralph

doi:10.1016/s0165-6147(98)01218-8

Cited by 34 publications

(3 citation statements)

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“…Clinically, gestational exposure to selective serotonin reuptake inhibitors (SSRIs) is associated with adolescent diagnosis of depression and speech disorders [ 43 , 44 ] with a potential for an elevated risk of autism spectrum disorder diagnosis [ 45 , 46 , 47 ] although this remains controversial. A key issue is that, during development, serotonin most particularly has trophic effects that influence the ontogenesis of neurons and the organization of the nervous system [ 29 , 48 , 49 , 50 , 51 , 52 ]. This influence may occur either locally or through the maternal-placental-fetal forebrain pathway [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring

et al. 2018

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In addition to transmitter functions, many neuroamines have trophic or ontogenetic regulatory effects important to both normal and disordered brain development. In previous work (Mejia et al., 2002), we showed that pharmacologically inhibiting monoamine oxidase (MAO) activity during murine gestation increases the prevalence of behaviors thought to reflect impulsivity and aggression. The goal of the present study was to determine the extent to which this treatment influences dopamine and serotonin innervation of murine cortical and subcortical areas, as measured by regional density of dopamine (DAT) and serotonin transporters (SERT). We measured DAT and SERT densities at 3 developmental times (PND 14, 35 and 90) following inhibition of MAO A, or MAO B or both throughout murine gestation and early post-natal development. DAT binding was unaltered within the nigrostriatal pathway, but concurrent inhibition of MAO-A and MAO-B significantly and specifically reduced SERT binding by 10–25% in both the frontal cortex and raphe nuclei. Low levels of SERT binding persisted (PND 35, 90) after the termination (PND 21) of exposure to MAO inhibitors and was most marked in brain structures germane to the previously described behavioral changes. The relatively modest level of enzyme inhibition (25–40%) required to produce these effects mandates care in the use of any compound which might inhibit MAO activity during gestation.

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Section: Discussionmentioning

confidence: 99%

Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring

et al. 2018

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“…Dopamine is a catecholamine neurotransmitter that is implicated in ontogenesis and embryonic germinal zone proliferation during development, and modulates movement, mood and motivation in the adult brain [160–162]. Dopamine receptors are classified as either D1-like (D1 and D5) or D2-like (D2, D3, and D4), according to structural homologies and shared second messenger cascades [163].…”

Section: Neurotransmittersmentioning

confidence: 99%

Signaling mechanisms regulating adult neural stem cells and neurogenesis

Faigle

Song

2013

Biochimica et Biophysica Acta (BBA) - General Subjects

294

258

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Background Adult neurogenesis occurs throughout life in discrete regions of the mammalian brain and is tightly regulated via both extrinsic environmental influences and intrinsic genetic factors. In recent years, several crucial signaling pathways have been identified in regulating self-renewal, proliferation, and differentiation of neural stem cells, as well as migration and functional integration of developing neurons in the adult brain. Scope of review Here we review our current understanding of signaling mechanisms, including Wnt, notch, sonic hedgehog, growth and neurotrophic factors, bone morphogenetic proteins, neurotransmitters, transcription factors, and epigenetic modulators, and crosstalk between these signaling pathways in the regulation of adult neurogenesis. We also highlight emerging principles in the vastly growing field of adult neural stem cell biology and neural plasticity. Major conclusions Recent methodological advances have enabled the field to identify signaling mechanisms that fine-tune and coordinate neurogenesis in the adult brain, leading to a better characterization of both cell-intrinsic and environmental cues defining the neurogenic niche. Significant questions related to niche cell identity and underlying regulatory mechanisms remain to be fully addressed and will be the focus of future studies. General significance A full understanding of the role and function of individual signaling pathways in regulating neural stem cells and generation and integration of newborn neurons in the adult brain may lead to targeted new therapies for neurological diseases in humans.

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“…Dopamine is a neurotransmitter of catecholamine that is involved in ontogenesis and embryonic proliferation of the germinal zone during development, and modulates movement, mood and motivation in the adult brain [ 207 ]. Dopamine receptors are classified as D1-like (D1 and D5) or D2-like (D2, D3 and D4), according to structural homologies and shared cascades of second messengers [ 208 ].…”

Section: Neurotransmittersmentioning

confidence: 99%

Cell Signaling in Neuronal Stem Cells

Quiroz

Ahmad

et al. 2018

Cells

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The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

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Discussion

Cited by 34 publications

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Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring

Perinatal MAO Inhibition Produces Long-Lasting Impairment of Serotonin Function in Offspring

Signaling mechanisms regulating adult neural stem cells and neurogenesis

Cell Signaling in Neuronal Stem Cells

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