Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Güler, Tuba; Aslan, Nurşad; Garip, Yeşim; Dörtbaş, Fulya; Karci, Ayşe Aslıhan

doi:10.5336/medsci.2017-56200

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…32 In previous studies, it has been reported that fatigue levels are high among patients with FMF and BD. 32,33 Similarly, in our study we found moderate fatigue before confinement in both BD and FMF patient groups, but we also found an increase in fatigue levels in both groups during confinement; for patients with BD, this increase was found to be statistically significant. We found that fatigue was associated with fatigue, vitality, general health, bodily pain, and mental health in BD patients, and role physical and vitality in FMF patients.…”

Section: Discussionsupporting

confidence: 82%

“…32,35 In a study conducted in BD patients in 2017, they reported pain as 39.85±31.59 according to 100 mm Visual Analogue Scale. 33 Similarly, in our study, the resting-pain and activity-pain scores before confinement were close to 4 according to the 10-point NRS. In confinement, we found a statistically significant increase in pain both during activity and at rest.…”

Section: Discussionsupporting

confidence: 81%

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Covid 19 Pandemi’sinde Behçet hastalığı ve Ailesel Akdeniz Ateşi hastalığında fiziksel aktivite düzeyi, uyku, yorgunluk ve yaşam kalitesi

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Tarakçı

Uğurlu

2023

Journal of Exercise Therapy and Rehabilitation

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urpose. The primary aim of our study was to compare the changes in physical activity, sleep, fatigue, pain, and quality of life levels between before confinement and during confinement in patients with Behçet and FMF. The secondary aim of the present study was to determine the exercise behavior of patients with Behçet and FMF during confinement. Methods. A total of 21 patients with Behcet Disease (Median age was 42, 57.1% were female) and 21 patients with FMF (Median age was 39, 71.4% were female) were included in this cross-sectional study. They completed Internal Physical Activity Questionnaire- Short Form (IPAQ-SF), Short Form 36 (SF-36) and Exercise Stages of Change Questionnaire. Sleep satisfaction, fatigue and pain was assessed with the Numeric Rating Scale (NRS). Results. There were no significant differences in sociodemographic data and all outcome scores except sleep duration between the groups at baseline (p>0.05). Both BD and FMF disease have been affected negatively by the confinement process. PA, Pain, Fatigue and Quality of life were adversely affected in Behçet's patients, while PA and quality of life were adversely affected in FMF patients. we found a significant relationship between physical activity and mental health subscale of quality of life in behçet's patients. In addition, only 9.5% of Behçet's patients and only 14.3% of FMF patients in our study stated that they had been exercising for more than 6 months. Conclusion. The patients in both groups were physically inactive and the majority of them did not exercise. this situation increased during the confinement period. Personalized exercise therapy and increasing physical activity in patients with BD and FMF will improve these symptoms.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Covid 19 Pandemi’sinde Behçet hastalığı ve Ailesel Akdeniz Ateşi hastalığında fiziksel aktivite düzeyi, uyku, yorgunluk ve yaşam kalitesi

Uzun

Tarakçı

Uğurlu

2023

Journal of Exercise Therapy and Rehabilitation

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“…Furthermore, the authors suggested genital ulcers as well as the involvement of eye and CNS as the leading causes of impairment in patients' quality of life. Besides, in another study by Guler et al, oral ulcers and skin lesions were two further clinical manifestations of Behcet's disease that altered the patients' physical, social, and emotional functioning and led to impaired quality of life [48]. However, our results showed no significant correspondence between Behcet's disease patients' wellness and health status and clinical manifestations, including ocular involvement, genital aphthous, and dermal lesions.…”

Section: Discussioncontrasting

confidence: 77%

Association of lifestyle elements with self-rated wellness and health status in patients with Behcet’s disease

et al. 2020

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Background Assessment of the association of various lifestyle factors and wellness and health status in patients with Behcet’s disease was the main goal of this study. Methods Demographic information, body mass index, smoking habit, mood status, sleep quality, physical activity levels, nutritional data, symptoms, signs, laboratory findings and patient reported outcome (self-rated wellness and health) in 52 patients with Behcet’s disease were collected in this cross-sectional study. A multivariable linear regression model was used to assess the association of self-rated wellness and health status and lifestyle factors, adjusted for age, sex, BMI, major symptoms and signs, as well as laboratory findings. Results Female to male ratio was 21/31, and the mean age of participants was 44 years. Mean self-rated wellness and health score was 14.6 out of 20. Oral and genital aphthous, ocular involvement, pathergy, and skin involvement were observed in 100, 52, 92, 36.5, and 9.5% of patients, respectively. The mean values of sleep, mood and nutrition quality scores were 17.7 (out of 70), 13.8 (out of 35), and 9 (out of 21), respectively. Univariable regression analysis showed a significant association between sleep quality, mood status, and disease duration, with patients’ status in terms of self-rated wellness and health. In multivariable linear regression, sleep quality was the only significant predictive variable associated with self-rated wellness and health. Conclusion Sleep quality was the most important factor associated with low self-rated wellness and health status in patients with Behcet’s disease.

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“…Oral ulcers can lead to poor dental hygiene, [14][15][16] limit essential daily activities like eating and talking, 16 and impair quality of life (QoL) overall and across several domains, such as physical and social functioning, sleep and fatigue, and mental health. 8,[17][18][19] Furthermore, patients with BD who have oral ulcers have reduced QoL compared with healthy controls and patients with other chronic conditions. 17,20 The European League Against Rheumatism (EULAR) is the primary source of treatment recommendations for BD-associated oral ulcers.…”

Section: Introductionmentioning

confidence: 99%

Comparability of European League Against Rheumatology-Recommended Pharmacological Treatments of Oral Ulcers Associated with Behçet’s Disease: A Systematic Literature Review of Randomized Controlled Trials

Nazareth

Hart

Ronnebaum

et al. 2020

OARRR

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Objective Oral ulcers are the cardinal manifestation in Behçet’s disease (BD). The 2018 European League Against Rheumatism (EULAR) recommendations describe treatments for BD-associated oral ulcers with mucocutaneous involvement; however, little comparative effectiveness information for these agents is available. In the absence of head-to-head trials, an indirect treatment comparison (ITC) could provide useful evidence regarding comparative effectiveness of BD treatments. The purpose of this study was to conduct a comparative systematic literature review (SLR) and similarity assessment of randomized controlled trials (RCTs) investigating the oral ulcer-related efficacy outcomes of EULAR-recommended treatments for BD-associated oral ulcers to determine the feasibility of an ITC. Methods An SLR was performed to identify relevant RCTs indexed in MEDLINE/Embase before May 29, 2019. RCT similarities for the ITC were assessed based on a step-wise process recommended by the International Society for Pharmacoeconomics and Outcomes Research. Results In total, 317 articles were identified, of which 14 RCTs, reflecting 11 EULAR-recommended treatments, were evaluated in a similarity assessment. Number of oral ulcers, resolution of oral ulcers, and healing time for oral ulcers were identified as the possible oral ulcer-related outcomes. After completing the similarity assessment of these outcomes, it was determined that a robust ITC was infeasible for the three oral ulcer-related outcomes due to heterogeneity in outcomes reporting, study design, and/or patient characteristics. More broadly, the results underscore the need for and consistent use of standardized measures for oral ulcer outcomes to facilitate comparative research. Conclusion In the absence of head-to-head RCTs and infeasibility of quantitative ITC, comparative assessments for BD-associated oral ulcers are limited, including comparative effectiveness and cost-effectiveness evaluations. Healthcare decision-makers must continue to base treatment decisions on the extent and strength of available evidence (eg, robust RCTs), clinical guidelines, real-world experience, and patient considerations.

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Disease Activity in Turkish Patients with Behçet's Disease: Association with Fatigue, Psychological Status and Quality of Life

Cited by 4 publications

References 25 publications

Covid 19 Pandemi’sinde Behçet hastalığı ve Ailesel Akdeniz Ateşi hastalığında fiziksel aktivite düzeyi, uyku, yorgunluk ve yaşam kalitesi

Covid 19 Pandemi’sinde Behçet hastalığı ve Ailesel Akdeniz Ateşi hastalığında fiziksel aktivite düzeyi, uyku, yorgunluk ve yaşam kalitesi

Association of lifestyle elements with self-rated wellness and health status in patients with Behcet’s disease

Comparability of European League Against Rheumatology-Recommended Pharmacological Treatments of Oral Ulcers Associated with Behçet’s Disease: A Systematic Literature Review of Randomized Controlled Trials

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