Disease Activity Score (DAS) Correlation to Serum Prolidase as a Collagen Turnover Marker in Comparison to Some Pro-inflammatory Markers in Rheumatoid Arthritis Patients: Clinical and Sonographic Study

Abstract

Objectives: Disease activity score (DAS) correlation to serum prolidase in comparison to other pro-inflammatory markers in rheumatoid arthritis (RA) cases.
 Method: Forty RA cases and 40 age and sex matched controls were studied in this case-control study. Cases fulfilled the 2010 American college of rheumatology (ACR)/ European League Against rheumatism (EULAR) RA classification criteria. Disease activity was assessed by the disease activity score 28 (DAS 28). Ultrasound (US) scanning of synovitis in pre-selected joint was done in both gray scale (GS) and power doppler US (PDUS) modes.
 Results: The cases’ mean age was 50.05 ± 7.99 years, 52 females and 28 males participated in this study. The mean disease duration was 6.10 ± 3.89 years and the mean for the DAS-28 score was 4.85 ± 1.04. There was a significant correlation between CRPM and DAS 28 score (r=0.323, p=0.042). IL-6 correlated with GS synovitis in the wrist (r=0.376, p= 0.017), MCP (r=0.430, p= 0.006) and PIP (r=0.653, p=<0.001) joints. Serum prolidase correlated with both GS synovitis in the wrist (r= 0.486, p=0.001) and MCP (r=0.604, p=<0.001) and PDUS synovitis in the wrist (r=0.334, p=0.035), and MCP joints (r=0.456, p=0.003). Regression analysis showed that IL-6 level had a greater impact on GS synovitis (p= <0.001), compared with serum prolidase.
 Conclusions: Serum IL-6 and prolidase has significant correlations with disease activity parameters compared with other markers. Serum prolidase is evidence on increased collagen turnover in RA cases and might be a useful tool in the assessment of joint inflammation and predicting future damage.

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

“…To diagnose RA, a variety of methods are utilized, including the assessment of risk factors, family history, joint ultrasound sonography, assessment of laboratory indicators including high C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in blood, discovery of RA-specific autoantibodies, and others [ 57 ]. CRP and ESR are frequently used as clinical indicators to assess the overall inflammatory status of patients with RA [ 58 ].…”

The Concordance of Patient-Reported Symptoms, Physical Examination and Ultrasound-Detected Synovitis, in Active Rheumatoid Arthritis

“…Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that predominantly affects the joints, leading to progressive cartilage and bone damage, and, if left untreated, can culminate in irreversible joint destruction (1,2). Characterized by hypertrophy and inflammation of the synovial membrane, RA's prevalence varies globally, affecting approximately 0.5 to 1% of the world's population, with a predilection for women, who are three times more likely than men to be diagnosed with the condition (3).…”

“…Characterized by hypertrophy and inflammation of the synovial membrane, RA's prevalence varies globally, affecting approximately 0.5 to 1% of the world's population, with a predilection for women, who are three times more likely than men to be diagnosed with the condition (3). The management and monitoring of RA involve the use of several composite indices, including the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI) (2,4). These tools are essential for planning effective management strategies; however, they are limited by the reproducibility of clinical examinations, which may not adequately detect subclinical synovitis associated with progressive joint damage (5).…”