Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook

Joseph, Josiane; Doles, Jason D.

doi:10.1186/s12986-021-00565-0

Cited by 11 publications

(10 citation statements)

References 86 publications

(69 reference statements)

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“…In chronic illness, there may be a chronic injury to the muscle depending on the severity and type of disease. Alterations in energy metabolism, inflammation, or restriction of movement can be factors that cause changes in satellite cells’ activity in diseased states [ 65 , 66 ]. Han et al reported that an increase in extracellular adenosine (eADO) in diabetic mice decreased the regenerative function of satellite cells [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies

et al. 2022

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The non-classical role of vitamin D has been investigated in recent decades. One of which is related to its role in skeletal muscle. Satellite cells are skeletal muscle stem cells that play a pivotal role in skeletal muscle growth and regeneration. This systematic review aims to investigate the effect of vitamin D on satellite cells. A systematic search was performed in Scopus, MEDLINE, and Google Scholar. In vivo studies assessing the effect of vitamin D on satellite cells, published in English in the last ten years were included. Thirteen in vivo studies were analyzed in this review. Vitamin D increases the proliferation of satellite cells in the early life period. In acute muscle injury, vitamin D deficiency reduces satellite cells differentiation. However, administering high doses of vitamin D impairs skeletal muscle regeneration. Vitamin D may maintain satellite cell quiescence and prevent spontaneous differentiation in aging. Supplementation of vitamin D ameliorates decreased satellite cells’ function in chronic disease. Overall, evidence suggests that vitamin D affects satellite cells’ function in maintaining skeletal muscle homeostasis. Further research is needed to determine the most appropriate dose of vitamin D supplementation in a specific condition for the optimum satellite cells’ function.

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Section: Discussionmentioning

confidence: 99%

Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies

et al. 2022

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“…Muscle satellite cells are essential in skeletal muscle fibre regeneration and repair (42,43). In addition, a decline in satellite cell content has been hypoth-esised to be an important contributing factor in the development of skeletal muscle fibre atrophy in aging as well as various other myopathies (44,45). Although the muscle fibres of LDH patients clearly show more muscle fibre damage based on centrally located myonuclei, satellite cell content was not different compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation

Stevens¹,

Agten²,

Snijders³

et al. 2022

Muscle Ligaments and Tendons J

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Background. Lumbar disc herniation (LDH) is the most common diagnosed degenerative pathology in the lumbar spine. Because of its role in spinal stability there is an increased interest in the role of the Lumbar Multifidus muscle in low back pain research. Despite surgical treatment long-term, disability and pain remain a persistent problem. The aim of the study is to compare side-to-side Lumbar Multifidus muscle fibre characteristics in unilateral LDH patients, and compare both sides to a healthy control group. Methods. Thirty patients (n = 17 men and n = 13 women) scheduled for microdiscectomy for unilateral disc herniation and ten healthy controls (n = 5 men and n = 5 women) were included in this study. Biopsies of the Lumbar Multifidus muscle were analysed by means of immunohistochemistry combined with immunofluorescence microscopy to determine type I and type II muscle fibre type distribution, cross-sectional area, myonuclear-and satellite cell content, inflammation and various indices of muscle fibre capillarisation. Results. The proportion of muscle fibres with centrally located myonuclei, various indicis of muscle fibre capillarisation and pro-and anti-inflammatory cell content were higher in the patients compared with the healthy controls. No differences were observed in type I and type II muscle fibre characteristics between the injured and uninjured side within the LDH patients. Conclusions. This study shows clear differences in Lumbar Multifidus muscle fibre characteristics between LDH patients, irrespective of injured or uninjured side, and healthy controls. Additional studies are warranted to establish the clinical significance of these differences in muscle fibre morphology in LDH compared with healthy controls. Study registration. This trial was registered on ClinicalTrials.gov under the identification number NCT03753711.

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“…Under the pressure of differentiation, myoblasts require more energy to maintain cell remodeling; accordingly mitochondria are constantly splitting in cells, and mitochondrial autophagy is markedly increased ( Hardy et al, 2016 ; Bloemberg and Quadrilatero, 2019 ). Mitochondrial renewal disorder has been repeatedly shown to reduce the differentiation ability of cultured myoblasts and the regeneration ability of skeletal muscle tissue ( Baechler et al, 2019 ; Joseph and Doles, 2021 ; Qualls et al, 2021 ). Enhancing mitochondrial biogenesis can improve muscle regeneration ( Niu et al, 2021 ).…”

Section: The Role Of Mitochondria In Myogenesis Regeneration and Musc...mentioning

confidence: 99%

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

Yan

Lin

et al. 2022

Front. Pharmacol.

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Skeletal muscle is one of the largest organs in the body and the largest protein repository. Mitochondria are the main energy-producing organelles in cells and play an important role in skeletal muscle health and function. They participate in several biological processes related to skeletal muscle metabolism, growth, and regeneration. Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor and regulator of systemic energy balance. AMPK is involved in the control of energy metabolism by regulating many downstream targets. In this review, we propose that AMPK directly controls several facets of mitochondrial function, which in turn controls skeletal muscle metabolism and health. This review is divided into four parts. First, we summarize the properties of AMPK signal transduction and its upstream activators. Second, we discuss the role of mitochondria in myogenesis, muscle atrophy, regeneration post-injury of skeletal muscle cells. Third, we elaborate the effects of AMPK on mitochondrial biogenesis, fusion, fission and mitochondrial autophagy, and discuss how AMPK regulates the metabolism of skeletal muscle by regulating mitochondrial function. Finally, we discuss the effects of AMPK activators on muscle disease status. This review thus represents a foundation for understanding this biological process of mitochondrial dynamics regulated by AMPK in the metabolism of skeletal muscle. A better understanding of the role of AMPK on mitochondrial dynamic is essential to improve mitochondrial function, and hence promote skeletal muscle health and function.

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Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook

Cited by 11 publications

References 86 publications

Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies

Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies

Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

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