Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China

Yang, Juan; Chen, Xinhua; Deng, Xiaowei; Chen, Zhiyuan; Gong, Hui; Yan, Han; Wu, Qianhui; Shi, Hui; Lai, Shengjie; Ajelli, Marco; Viboud, Cécile; Yu, Hongjie

doi:10.1038/s41467-020-19238-2

Cited by 100 publications

(84 citation statements)

References 45 publications

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“…SARS-CoV-2 emerged in the Hubei province of China by the end of 2019 and caused an epidemic that was partially contained in China by March 2020 ( 8 ). However, the virus rapidly spread globally and caused the pandemic.…”

Section: Introductionmentioning

confidence: 99%

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Milewska

Cheng

Szczepański

et al. 2021

J Virol

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Among seven coronaviruses that infect humans, three (SARS-CoV, MERS-CoV, and the newly identified SARS-CoV-2) are associated with a severe, life-threatening respiratory infection and multiorgan failure. We previously proposed that the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) is a potent inhibitor of HCoV-NL63. Next, we demonstrated the broad-spectrum antiviral activity of the compound, as it inhibited all low pathogenic human coronaviruses (HCoV-NL63, HCoV-229E, HCoV-OC43, and HCoV-HKU1). Here, using in vitro and ex vivo model of human airway epithelium, we show that HTCC effectively blocks MERS-CoV and SARS-CoV-2 infection. We also confirmed the mechanism of action for these two viruses, showing that the polymer blocks the virus entry to the host cell by interaction with the S protein. IMPORTANCE The beginning of 2020 brought us information about the novel coronavirus emerging in China. Rapid research resulted in the characterization of the pathogen, which appeared to be a member of the SARS-like cluster, commonly seen in bats. Despite the global and local efforts, the virus escaped the health care measures and rapidly spread in China and later globally, officially causing a pandemic and global crisis in March 2020. At present, different scenarios are being written to contain the virus, but the development of novel anticoronavirals for all highly pathogenic coronaviruses remains the major challenge. Here, we describe the antiviral activity of previously developed by us HTCC compound, which may be used as a potential inhibitor of currently circulating highly pathogenic coronaviruses – SARS-CoV-2 and MERS-CoV.

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Section: Introductionmentioning

confidence: 99%

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Milewska

Cheng

Szczepański

et al. 2021

J Virol

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“…[38,39,41]. (C) SARS-CoV-2 was first reported in humans in December 2019 in Wuhan, China [106]. (D) Successful laboratory infections of SARS-CoV-2 have been reported in the following mammals: domestic dogs, domestic cats, ferrets, rabbits, raccoon dogs, hamsters, mice, tree shrews, cattle, and several species of non-human primates [107,108].…”

Section: Sars-cov-2 Spike Protein and Ace-2mentioning

confidence: 99%

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

Hedman¹,

Krawczyk

Helmy

et al. 2021

Pathogens

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Emerging infectious diseases present great risks to public health. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become an urgent public health issue of global concern. It is speculated that the virus first emerged through a zoonotic spillover. Basic research studies have suggested that bats are likely the ancestral reservoir host. Nonetheless, the evolutionary history and host susceptibility of SARS-CoV-2 remains unclear as a multitude of animals has been proposed as potential intermediate or dead-end hosts. SARS-CoV-2 has been isolated from domestic animals, both companion and livestock, as well as in captive wildlife that were in close contact with human COVID-19 cases. Currently, domestic mink is the only known animal that is susceptible to a natural infection, develop severe illness, and can also transmit SARS-CoV-2 to other minks and humans. To improve foundational knowledge of SARS-CoV-2, we are conducting a synthesis review of its host diversity and transmission pathways. To mitigate this COVID-19 pandemic, we strongly advocate for a systems-oriented scientific approach that comprehensively evaluates the transmission of SARS-CoV-2 at the human and animal interface.

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“…In fact, so far not any plan of vaccine is in hands, clearly one must expects successive peaks and waves [3]. In addition public health operators are expected to attenuate the propagation of Covid-19 in vulnerable population [4]. and is also a substantial cause for economic tumble in developing countries [5].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Social Distancing Through the Probabilistic Weiss Equation: It is the Wind Velocity a Relevant Factor?

Nieto-Chaupis

2020

2020 International Conference on Computing, Networking, Telecommunications &Amp; Engineering Sciences Applications (CoNTESA)

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From the probabilistic Weiss equation, various relations involving the distance, wind velocity and number of people both healthy and infected, the critic distances that might be critic to transmit any virus strain, are calculated. The present approach considers as main criterion that the outdoor infection is a random event that depends of a plethora of variables and free parameters. We project the present theoretical proposal to the current Corona Virus Disease 2019 pandemic by which is established that people must keep a social distance ranging between 1.5m and 2.0m in order to avoid contact with aerosol. In this paper stochastic and deterministic equations are proposed as well as hybrid relationships that would explain facts in the action of outdoor infection. In this manner virus can be transmited in a radius of 2m for a wind velocity of 10m/s.

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Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China

Cited by 100 publications

References 45 publications

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface

Estimation of Social Distancing Through the Probabilistic Weiss Equation: It is the Wind Velocity a Relevant Factor?

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