2013
DOI: 10.1089/omi.2012.0053
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Disease Co-Morbidity and the Human Wnt Signaling Pathway: A Network-Wise Study

Abstract: The human Wnt signaling pathway contains 57 genes communicating among themselves by 70 experimentally established associations, as given in the KEGG/PATHWAY database. It is responsible for a variety of crucial biological functions such as regulation of cell fate determination, proliferation, differentiation, migration, and apoptosis. Abnormal behavior of its members causes numerous types of human cancers, dramatic changes in bone mass density that lead to diseases such as osteoporosis-pseudo-glioma syndrome, V… Show more

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Cited by 5 publications
(2 citation statements)
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“…IL-17 stimulates MMP-1 expression from fibroblasts ( 64 , 65 ). Sputum MMP-1 activity from patients with TB correlates with lung pathology ( 66 , 67 ). In the rabbit postprimary TB model, MMP-1 activity correlates spatially with tissue necrosis and pulmonary cavitation ( 26 ).…”
Section: Tissue Damage Mediated By Delayed-type Hypersensitivitymentioning
confidence: 99%
“…IL-17 stimulates MMP-1 expression from fibroblasts ( 64 , 65 ). Sputum MMP-1 activity from patients with TB correlates with lung pathology ( 66 , 67 ). In the rabbit postprimary TB model, MMP-1 activity correlates spatially with tissue necrosis and pulmonary cavitation ( 26 ).…”
Section: Tissue Damage Mediated By Delayed-type Hypersensitivitymentioning
confidence: 99%
“…These complex noncommunicable diseases (NCDs) are characterized by deterioration in multiple dimensions also related to lifestyle, genetics and hormones. Thus, osteoporosis and these chronic diseases are linked in a networking manner through the genetic factors that can be referred to as “diseasome.” In the Wnt pathway alone, on average each disease shared ∼15 neighbors with each other disease, indicating high comorbidity within the network [10] .…”
Section: Introductionmentioning
confidence: 99%