Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of 423 Japanese patients during a long-term follow-up: The JUDE study

Minowa, Kentaro; Amano, Hirofumi; Ando, Seiichiro; Watanabe, Takashi; Ogasawara, Michihiro; Kawano, Shinya; Kaneko, Tetsuya; Morimoto, Shinji; Yamaji, Katsuhiko; Tamura, Naoto; Tokano, Yoshiaki; Hashimoto, Hiroshi; Takasaki, Yoshinari

doi:10.1080/14397595.2016.1192745

Cited by 13 publications

(12 citation statements)

References 19 publications

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“…These differences may have been caused by the stringent inclusion criteria in the present study. However, the gender ratio and age distribution, with the exception of the elderly population, were similar to those described in previous studies …”

Section: Discussionsupporting

confidence: 88%

“…The mean (SD) number of flares per patient was 5.5 (3.3) times over the 3‐year study period, which increased with SLE severity (ANOVA, P < 0.001). The proportion of patients experiencing a severe flare during the study (105 patients, 35.6%) was consistent with the proportion of patients (31.9%) reported in a long‐term follow‐up, monocentric SLE cohort . The mean costs per flare increased with SLE severity, consistent with results of a study that applied chart reviews and patient‐reported questionnaires in patients with SLE in Hong Kong .…”

Section: Discussionsupporting

confidence: 80%

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Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 80%

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

et al. 2018

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“…Most of the patients (67.9%) experienced at least one disease flare within 10 years from diagnosis. This is in line with the JUDE study 26 that reported that in a Japanese cohort the majority of flares happened within the first 10 years from SLE onset, instead Swaak et al. in a multicentric study 18 found that 3-11% of patients had an exacerbation of disease during the last year of follow-up (median duration of SLE 16 years).…”

Section: Discussionsupporting

confidence: 85%

How do systemic lupus erythematosus patients with very-long disease duration present? Analysis of a monocentric cohort

Signorini

Tani

Elefante

et al. 2021

Lupus

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Objective to describe the disease path and the very long-term outcome in a monocentric cohort of patients with Systemic Lupus Erythematosus (SLE). Methods SLE patients with a disease duration of at least 15 years from diagnosis were enrolled. The number of hospitalizations, the disease flares occurred over the disease course and the organ damage accumulation were evaluated at 1, 2, 3, 4, 5, 10 years from diagnosis and at last observation in 2019 as well. Disease state, ongoing therapies and quality of life measures were also assessed at last visit. Results 126 Caucasian SLE patients were included in the analysis (95% female, median age 47.5 IQR 41–53, median disease duration 21 IQR19-26). At last visit, the majority of the patients (78.6%) was on LLDAS (remission included), 53.4% were on GC treatment and 35.7% on immunosuppressant. Furthermore, 53.2% had at least one organ damage. The majority of patients (66.7%) presented a relapsing-remitting course, for a total of 158 flares during the disease course (incidence rate: 0.79/patient-year); moreover, 84.9% of the cohort experienced at least one hospital admission, amounting to a total of 328 hospitalizations (incidence rate: 0.85/patient-year). The main reason for admission was disease activity, while the percentage of hospitalizations due to other causes has been growing over the 10 years of follow-up. Conclusion after a very long period of disease, most of the patients with SLE are in remission and are not taking GC therapy; however, the risk of incurring in disease flare remains a real problem.

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“…5 Moreover, a single-centre cohort study in Japan confirmed that thrombocytopaenia at onset was a predictive factor for flares and that treatment guidelines for thrombocytopaenia should be improved in the long term. 30 Both clinical practice and published studies suggested that thrombocytopaenia was associated with multiple organ damage in SLE. 25 In this study, univariate analysis showed that SLE patients with thrombocytopaenia had more severe clinical manifestations, including neurological manifestations, oral mucosal ulceration, pleurisy, pericarditis, hyperglycaemia, leucocytopaenia, urinary casts, haematuria and pyuria.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and influential factors of thrombocytopaenia in systemic lupus erythematosus patients: a retrospective analysis of 3140 cases in a Chinese population

Mao

Shi

et al. 2020

Lupus

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Introduction The present study aimed to investigate the prevalence and influential factors of thrombocytopaenia in systemic lupus erythematosus (SLE) patients among the Chinese population in order to provide evidence for improving the treatment and nursing of SLE patients. Methods A retrospective analysis of 3140 SLE patients admitted to two large tertiary hospitals was conducted in Anhui, China, from 2011 to 2018. In addition, the influential factors related to SLE with thrombocytopaenia were analysed through univariate and multivariate analysis. Results A total of 804 SLE patients had thrombocytopaenia (25.6%). The top 5 clinical manifestations of SLE inpatients were proteinuria (51.0%), lupus nephritis (45.9%), new rash (38.4%), haematuria (36.7%) and pyuria (32.2%). The incidence of neurological manifestations, oral mucosal ulceration, pleurisy, pericarditis, hyperglycaemia, leucocytopaenia, urinary casts, haematuria, pyuria and high disease activity in the thrombocytopaenia group were higher than those in the non-thrombocytopaenia group ( p < 0.05). Multivariate analysis showed age (odds ratio (OR) = 1.009, p = 0.005), neurological manifestations (OR = 1.373, p = 0.048), pericarditis (OR = 1.394, p = 0.048), hyperglycaemia (OR = 1.717, p < 0.001), leucocytopaenia (OR = 2.551, p < 0.001), haematuria (OR = 1.582, p < 0.001), serum C3 level <0.85 g/L (OR = 1.525, p = 0.001), serum C4 concentration <0.10 g/L (OR = 1.287, p = 0.020), serum CRP concentration <8 ng/L (OR = 1.314, p = 0.005), prothrombin time >15.30 seconds (OR = 1.479, p = 0.032), activated partial thromboplatin time >45 seconds (OR = 1.924, p < 0.001) and thrombin time >21 seconds (OR = 1.629, p = 0.015) were associated with thrombocytopaenia. Conclusion Thrombocytopaenia has a high prevalence in SLE patients and is related to some baseline, clinical and laboratory characteristics, affecting multiple organs and systems.

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Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of 423 Japanese patients during a long-term follow-up: The JUDE study

Abstract: Thrombocytopenia at onset is predictive factor for flares. Since SLE is a diverse disease with varying symptoms at recurrence, the treatment guidelines should be improved for thrombocytopenia from a long-term perspective.

Cited by 13 publications

References 19 publications

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

Disease severity and economic burden in Japanese patients with systemic lupus erythematosus: A retrospective, observational study

How do systemic lupus erythematosus patients with very-long disease duration present? Analysis of a monocentric cohort

Prevalence and influential factors of thrombocytopaenia in systemic lupus erythematosus patients: a retrospective analysis of 3140 cases in a Chinese population

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